Primary malignant myoepithelioma of the distal femur

A 55‐year‐old male presented with a 1‐month history of localized pain caused by an osteolytic and destructive lesion in the right distal femur. Histologically, the tumour consisted of spindle cells intermingled with epithelioid eosinophilic cells arranged in small cords embedded in a hyalinized‐to‐c...

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Bibliographic Details
Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2007-04, Vol.115 (4), p.376-380
Main Authors: ALBERGHINI, M., PASQUINELLI, G., ZANELLA, L., PIGNATTI, G., BENINI, S., BACCHINI, P., BERTONI, F.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bone Neoplasms - diagnosis
Bone Neoplasms - pathology
Femur - pathology
Fundamental and applied biological sciences. Psychology
Humans
Infectious diseases
Magnetic Resonance Imaging
Male
malignant mixed tumours
malignant myoepitheliomas
malignant myxoid tumours
Medical sciences
Microbiology
Middle Aged
Myoepithelioma - diagnosis
Myoepithelioma - pathology
Primary bone tumours
Tumors
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Summary:A 55‐year‐old male presented with a 1‐month history of localized pain caused by an osteolytic and destructive lesion in the right distal femur. Histologically, the tumour consisted of spindle cells intermingled with epithelioid eosinophilic cells arranged in small cords embedded in a hyalinized‐to‐chondromyxoid stroma. Electron microscopy and immunohistochemistry showed features of myoepithelial differentiation. RT‐PCR failed to demonstrate chimeric transcripts of extraskeletal myxoid chondrosarcoma. The final diagnosis was primary malignant myoepithelioma of bone. The patient is alive with lung metastases 13 months after surgery. Primary malignant myoepithelioma of bone is an exceptionally rare neoplasm that should be considered in the differential diagnosis with the more aggressive myxoid spindle cell sarcomas.
ISSN:0903-4641
1600-0463
DOI:10.1111/j.1600-0463.2007.apm_569.x