Hypoadiponectinemia as a Predictor for the Development of Hypertension: A 5-Year Prospective Study

Low circulating levels of adiponectin, an adipokine with insulin-sensitizing, antiatherogenic, and anti-inflammatory properties, are found in hypertensive patients. Adiponectin replenishment ameliorated hypertension in adiponectin-deficient mice or obese, hypertensive mice with hypoadiponectinemia,...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2007-06, Vol.49 (6), p.1455-1461
Main Authors: Chow, Wing-Sun, Cheung, Bernard M.Y, Tso, Annette W.K, Xu, Aimin, Wat, Nelson M.S, Fong, Carol H.Y, Ong, Liza H.Y, Tam, Sidney, Tan, Kathryn C.B, Janus, Edward D, Lam, Tai-Hing, Lam, Karen S.L
Format: Article
Language:English
Subjects:
Adiponectin - blood
Adiposity - physiology
Adult
Aged
Blood Pressure - physiology
Case-Control Studies
China - epidemiology
Cohort Studies
Female
Humans
Hypertension - blood
Hypertension - epidemiology
Insulin Resistance - physiology
Male
Middle Aged
Obesity - blood
Obesity - complications
Predictive Value of Tests
Prospective Studies
Risk Factors
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Summary:Low circulating levels of adiponectin, an adipokine with insulin-sensitizing, antiatherogenic, and anti-inflammatory properties, are found in hypertensive patients. Adiponectin replenishment ameliorated hypertension in adiponectin-deficient mice or obese, hypertensive mice with hypoadiponectinemia, suggesting an etiologic role of adiponectin in hypertension. We aimed to determine, in this 5-year prospective study, whether hypoadiponectinemia could predict the development of hypertension in a nondiabetic Chinese cohort. A total of 577 subjects (249 men and 328 women) were recruited from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study and prospectively followed up for 5 years. The relationship of serum adiponectin with the development of hypertension (sitting blood pressure ≥140/90 mm Hg) was investigated in a nested case–control study consisting of 70 subjects who had developed hypertension on follow-up and 140 age- and sex-matched control subjects who were normotensive both at baseline and at year 5. At baseline, serum adiponectin level in the lowest sex-specific tertile was more likely to be associated with hypertension (P=0.003 versus the highest tertile, after adjusting for age, body mass index, fasting insulin, and high-sensitivity C-reactive protein). At year 5, baseline serum adiponectin was a significant independent predictor of incident hypertension in the nested case–control study (P=0.015; age adjusted), together with mean arterial pressure (P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.107.086835