Transmembrane B-DNA

The unique properties of rigid‐rod β‐barrels are used for the programmed assembly of transmembrane B‐DNA, a complex supramolecular architecture (see picture) that combines the advantages of biomembrane anisotropy with the structural variability of B‐DNA. Binding of B‐DNA in the intratoroidal space o...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2000-08, Vol.1 (2), p.123-125
Main Authors: Sakai, Naomi, Baumeister, Bodo, Matile, Stefan
Format: Article
Language:English
Subjects:
Cell Membrane - chemistry
Cell Membrane - metabolism
Circular Dichroism
DNA - chemistry
DNA - metabolism
Electron Transport
ion channels
Lipid Bilayers - chemistry
membranes
Models, Chemical
Nucleic Acid Conformation
Oligodeoxyribonucleotides - chemistry
oligonucleotides
protein mimetics
supramolecular chemistry
Surface Properties
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Summary:The unique properties of rigid‐rod β‐barrels are used for the programmed assembly of transmembrane B‐DNA, a complex supramolecular architecture (see picture) that combines the advantages of biomembrane anisotropy with the structural variability of B‐DNA. Binding of B‐DNA in the intratoroidal space of the nanopores (KD=177 nM) was confirmed by CD spectra and the blockage of anionic dye efflux.
ISSN:1439-4227
1439-7633
DOI:10.1002/1439-7633(20000818)1:2<123::AID-CBIC123>3.0.CO;2-C