Evidence of a role of endogenous estrogen in the modulation of autonomic nervous system

We studied heart rate variability in 14 healthy women before and after oophorectomy compared with 14 matched women who underwent hysterectomy with ovarian conservation. Surgical menopause induced a decline in cardiac vagal modulation with a shift toward sympathetic hyperactivity. Recovery of the bas...

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Bibliographic Details
Published in:The American journal of cardiology 2000-03, Vol.85 (6), p.787-789
Main Authors: Mercuro, G, Podda, A, Pitzalis, L, Zoncu, S, Mascia, M, Melis, G B, Rosano, G M
Format: Article
Language:English
Subjects:
Cardiovascular System - innervation
Case-Control Studies
Circulatory system
Estrogen Replacement Therapy
Estrogens
Estrogens - physiology
Female
Humans
Hysterectomy
Middle Aged
Nervous system
Ovariectomy
Postmenopause
Sympathetic Nervous System - physiology
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Summary:We studied heart rate variability in 14 healthy women before and after oophorectomy compared with 14 matched women who underwent hysterectomy with ovarian conservation. Surgical menopause induced a decline in cardiac vagal modulation with a shift toward sympathetic hyperactivity. Recovery of the baseline condition after 3 months of estrogen replacement therapy in oophorectomized women suggests a role of estrogen in the autonomic nervous control of the cardiovascular system.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(99)00865-6