Adiponectin Level and Left Ventricular Hypertrophy in Japanese Men

• Published in: Hypertension (Dallas, Tex. 1979) Tex. 1979), 2007-06, Vol.49 (6), p.1448-1454
• Main Authors: Mitsuhashi, Hirotsugu, Yatsuya, Hiroshi, Tamakoshi, Koji, Matsushita, Kunihiro, Otsuka, Rei, Wada, Keiko, Sugiura, Kaichiro, Takefuji, Seiko, Hotta, Yo, Kondo, Takahisa, Murohara, Toyoaki, Toyoshima, Hideaki
• Format: Article
• Language: English
• Subjects: Adiponectin - blood; Adiponectin - physiology; Adult; Aged; Biological and medical sciences; Body Mass Index; Cardiology. Vascular system; Electrocardiography; Electrocardiography. Vectocardiography; Electrodiagnosis. Electric activity recording; Heart; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Humans; Hypertrophy, Left Ventricular - blood; Hypertrophy, Left Ventricular - epidemiology; Hypertrophy, Left Ventricular - physiopathology; Investigative techniques, diagnostic techniques (general aspects); Japan - epidemiology; Logistic Models; Male; Medical sciences; Middle Aged; Odds Ratio; Prevalence
• ISSN: 0194-911X; 1524-4563
• DOI: 10.1161/HYPERTENSIONAHA.106.079509

A recent study has demonstrated that adiponectin inhibited hypertrophic signaling in the myocardium of mice, implying that a decrease in the blood adiponectin level could cause cardiac muscle hypertrophy. We hypothesized that a relationship might exist between the serum adiponectin level and electrocardiographically diagnosed left ventricular hypertrophy (ECG-LVH), and we examined this hypothesis by epidemiological study of 2839 Japanese male workers who were not taking medications for hypertension. ECG-LVH was defined as meeting Sokolow–Lyon voltage criteria and/or Cornell voltage-duration product. The subjects were categorized by tertiles of serum adiponectin level, and a multivariate logistic regression analysis was conducted relating left ventricular hypertrophy to adiponectin tertiles adjusting for potential confounding factors. Prevalence of ECG-LVH in the studied sample was 16.7%. Adiponectin ranged from 1.0 to 5.0 μg/mL in the lowest category and from 7.4 to 30.6 μg/mL in the highest. Compared with subjects in the highest adiponectin category, those in the lowest one had a significantly higher prevalence of ECG-LVH independent of age, body mass index, and systolic blood pressure with an odds ratio of 1.50 and a 95% CI of 1.16 to 1.94. Further adjustment for high-density lipoprotein cholesterol, triglyceride, and insulin resistance did not change the association (odds ratio1.68; 95% CI1.28 to 2.21; P