The involvement of AT(2)-receptor in the antithrombotic effect of losartan in renal hypertensive rats

In previous studies, we have shown that losartan possesses nitric oxide-dependent antithrombotic properties in various models of hypertension in rats. It was demonstrated that stimulation of AT2-receptors plays an important role in the pharmacological effects of AT1-receptor antagonists. Thus, in th...

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Bibliographic Details
Published in:Journal of the renin-angiotensin-aldosterone system 2000-09, Vol.1 (3), p.263-267
Main Authors: Chabielska, E, Matys, T, Kucharewicz, I, Pawlak, D, Rólkowski, R, Buczko, W
Format: Article
Language:English
Subjects:
Animals
Antihypertensive Agents - pharmacology
Blood Pressure - drug effects
Fibrinolytic Agents - pharmacology
Hypertension, Renovascular - physiopathology
Imidazoles - pharmacology
Ligation
Losartan - pharmacology
Male
Pyridines - pharmacology
Rats
Rats, Wistar
Receptor, Angiotensin, Type 2
Receptors, Angiotensin - agonists
Receptors, Angiotensin - physiology
Venae Cavae
Venous Thrombosis - prevention & control
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Summary:In previous studies, we have shown that losartan possesses nitric oxide-dependent antithrombotic properties in various models of hypertension in rats. It was demonstrated that stimulation of AT2-receptors plays an important role in the pharmacological effects of AT1-receptor antagonists. Thus, in this study, we examine the participation of AT2-receptors in the antithrombotic action of losartan in renal hypertensive rats on venous thrombosis induced by a two-hour ligation of the vena cava. Losartan administration(30 mg/kg, p.o.) resulted in a marked decrease in thrombus weight (by 85%, p
ISSN:1470-3203