Effects of zolpidem and zopiclone on cognitive and attentional function in young healthy volunteers: An event‐related potential study

The effects of zolpidem and zopiclone, non‐benzodiazepine ultra‐short‐acting hypnotics, on cognitive function and vigilance level were investigated in the morning following nocturnal administration using event‐related potentials (ERP) and a sleep latency test (SLT). Zopiclone significantly shortened...

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Bibliographic Details
Published in:Psychiatry and clinical neurosciences 2000-02, Vol.54 (1), p.37-40
Main Authors: Nakajima, Toru, Takazawa, Satoru, Hayashida, Seiki, Nakagome, Kazuyuki, Sasaki, Tsukasa, Kanno, Osamu
Format: Article
Language:English
Subjects:
Adult
Attention - drug effects
Azabicyclo Compounds
Cognition - drug effects
Cognitive functioning
Cross-Over Studies
Double-Blind Method
Event related brain potentials
Event-Related Potentials, P300 - drug effects
event‐related potentials
Female
Half-Life
Humans
Hypnotics
Hypnotics and Sedatives - administration & dosage
Hypnotics and Sedatives - pharmacokinetics
Hypnotics and Sedatives - pharmacology
Japan
Male
Men
mismatch negativity
negative difference
Piperazines - pharmacology
Placebos
Pyridines - administration & dosage
Pyridines - pharmacokinetics
Pyridines - pharmacology
sleep latency test
Vigilance
zolpidem
zopiclone
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Summary:The effects of zolpidem and zopiclone, non‐benzodiazepine ultra‐short‐acting hypnotics, on cognitive function and vigilance level were investigated in the morning following nocturnal administration using event‐related potentials (ERP) and a sleep latency test (SLT). Zopiclone significantly shortened the sleep latency the following morning, whereas zolpidem did not, perhaps due to the difference in the elimination half‐lives between the compounds. No significant effect was observed for either drug on the ERP indices, including the P3, mismatch negativity and negative difference components. At a clinically prescribed dosage these sleep inducers have no remarkable effect on cognitive or attentional functions but increase sleepiness of the subjects.
ISSN:1323-1316
1440-1819
DOI:10.1046/j.1440-1819.2000.00634.x