Cholinergic activity of aged rhesus monkeys revealed by positron emission tomography

In the present study, the radiotracer [18F] (+)‐4‐fluorobenzyltrozamicol ((+)‐[18F]FBT) and positron emission tomography (PET) were used to examine the vesicular acetylcholine transporter and determine if presynaptic cholinergic activity was altered with age in 23 rhesus monkeys that varied in age f...

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Bibliographic Details
Published in:Synapse (New York, N.Y.) N.Y.), 2001-01, Vol.39 (1), p.95-100
Main Authors: Voytko, Mary Lou, Mach, Robert H., Gage, H. Donald, Ehrenkaufer, Richard L.E., Efange, Simon M.N., Tobin, Joseph R.
Format: Article
Language:English
Subjects:
Acetylcholine - metabolism
aging
Aging - metabolism
Animals
Basal Ganglia - cytology
Basal Ganglia - metabolism
Carrier Proteins - metabolism
Cerebellum - cytology
Cerebellum - metabolism
cholinergic terminals
Fluorine Radioisotopes
Fluorobenzenes - pharmacokinetics
functional imaging
individual differences
Macaca mulatta
Macaca mulatta - anatomy & histology
Macaca mulatta - metabolism
Male
Membrane Transport Proteins
Neuromuscular Depolarizing Agents - agonists
Piperidines - agonists
Piperidines - pharmacokinetics
Presynaptic Terminals - metabolism
Presynaptic Terminals - ultrastructure
rhesus monkey
Tomography, Emission-Computed
Vesicular Acetylcholine Transport Proteins
vesicular acetylcholine transporter
Vesicular Transport Proteins
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Summary:In the present study, the radiotracer [18F] (+)‐4‐fluorobenzyltrozamicol ((+)‐[18F]FBT) and positron emission tomography (PET) were used to examine the vesicular acetylcholine transporter and determine if presynaptic cholinergic activity was altered with age in 23 rhesus monkeys that varied in age from 10 to 37 years. Binding of (+)‐[18F]FBT in the basal ganglia was reduced significantly with increasing age of the monkeys. However, there were individual differences noted in that some middle‐aged and aged monkeys demonstrated levels of (+)‐[18F]FBT binding that were comparable to the binding measured in adult monkeys. These data indicate that presynaptic cholinergic function may decrease with age, but that there may be a differential susceptibility of the cholinergic system to the aging process in different individuals. Synapse 39:95–100, 2001. © 2001 Wiley‐Liss, Inc.
ISSN:0887-4476
1098-2396
DOI:10.1002/1098-2396(20010101)39:1<95::AID-SYN12>3.0.CO;2-2