Effects of a single injection of methylprednisolone acetate on serum biochemical parameters in 11 cats

Background: Therapeutic use of corticosteroids has been implicated in a variety of serum biochemical abnormalities in dogs; however, the effects in cats are less well characterized. Objective: The objective of this brief communication is to report serum biochemical changes in response to methylpredn...

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Bibliographic Details
Published in:Veterinary clinical pathology 2007-06, Vol.36 (2), p.184-187
Main Authors: Sharkey, L.C, Ployngam, T, Tobias, A.H, Torres, S.M.F
Format: Article
Language:English
Subjects:
adult animals
adverse effects
alkaline phosphatase
amylases
Animals
Blood Chemical Analysis - veterinary
blood chemistry
blood serum
Cat
Cat Diseases - blood
Cat Diseases - drug therapy
cats
Cats - blood
drug injection
drug therapy
enzyme activity
feline
intramuscular injection
methylprednisolone
Methylprednisolone - analogs & derivatives
Methylprednisolone - pharmacology
methylprednisolone acetate
prednisolone
serum albumin
serum biochemistry
skin diseases
Skin Diseases - blood
Skin Diseases - drug therapy
Skin Diseases - veterinary
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Summary:Background: Therapeutic use of corticosteroids has been implicated in a variety of serum biochemical abnormalities in dogs; however, the effects in cats are less well characterized. Objective: The objective of this brief communication is to report serum biochemical changes in response to methylprednisolone acetate (MPA) in adult cats. Methods: Serum biochemical profiles were performed on 11 cats with dermatologic diseases at baseline, 3–6 days, and 16–24 days after a single intramuscular dose of 5 mg/kg MPA. Results: Median serum albumin and bicarbonate concentrations and amylase activity were increased compared to baseline at both post‐treatment time points; aspartate aminotransferase activity and magnesium concentration were increased at 3–6 days post‐treatment only; and alkaline phosphatase activity and total calcium concentration were increased at 16–24 days post‐treatment only. Median serum creatinine concentration was decreased compared to baseline at both post‐treatment time points. Examination of data from individual cats revealed significant variability in serum biochemical changes in response to MPA. No adverse clinical reactions to the drug were reported. Conclusions: A single dose of MPA results in significant changes in some serum biochemical values in cats, although individual responses will vary.
ISSN:0275-6382
1939-165X
DOI:10.1111/j.1939-165X.2007.tb00206.x