Sea buckthorn berry oil inhibits platelet aggregation

A small-scale preliminary cross-over study was conducted to investigate the effects of supercritical CO 2-extracted sea buckthorn berry oil (SBO) on some risk factors of cardiovascular disease. Special features of the oil are high proportions of palmitic (16:0), oleic (18:1n-9), palmitoleic (16:1n-7...

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Bibliographic Details
Published in:The Journal of nutritional biochemistry 2000-10, Vol.11 (10), p.491-495
Main Authors: Johansson, Anu K, Korte, Helena, Yang, Baoru, Stanley, John C, Kallio, Heikki P
Format: Article
Language:English
Subjects:
berry oil
Biological and medical sciences
cardiovascular disease
General pharmacology
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
platelet aggregation
sea buckthorn
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Summary:A small-scale preliminary cross-over study was conducted to investigate the effects of supercritical CO 2-extracted sea buckthorn berry oil (SBO) on some risk factors of cardiovascular disease. Special features of the oil are high proportions of palmitic (16:0), oleic (18:1n-9), palmitoleic (16:1n-7), linoleic (18:2n-6), and α-linolenic (18:3n-3) acids as well as vitamin E, carotenoids, and sterols. Twelve healthy normolipidemic men were recruited and each volunteer consumed SBO and fractionated coconut oil (control) 5 g per day for a period of 4 weeks in a random order (wash-out 4–8 weeks). Phospholipid fatty acids, plasma lipids, and glucose were unaffected by SBO supplementation. Instead, a clear decrease in the rate of adenosine-5′-diphosphate-induced platelet aggregation and maximum aggregation were found. This suggested the beneficial effects of SBO on blood clotting, but further studies on the dose-response effects are needed to assess the practical use of SBO supplements.
ISSN:0955-2863
1873-4847
DOI:10.1016/S0955-2863(00)00105-4