Clinical Contrast Sensitivity Testing in Patients With Infantile Nystagmus Syndrome Compared With Age-Matched Controls

Purpose To compare contrast sensitivity using a commercially available technique between patients with infantile nystagmus syndrome (INS) and controls. Design Prospective, comparative case series. Methods The functional acuity contrast test (FACT) was used binocularly in patients with INS and aged-m...

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Bibliographic Details
Published in:American journal of ophthalmology 2007-06, Vol.143 (6), p.1063-1065
Main Authors: Hertle, Richard W, Reese, Matthew
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Biological and medical sciences
Child
Child, Preschool
Contrast Sensitivity - physiology
Humans
Medical sciences
Miscellaneous
Nystagmus, Congenital - physiopathology
Oculomotor disorders
Ophthalmology
Prospective Studies
Retina
Syndrome
Variance analysis
Vision Tests - methods
Visual Acuity - physiology
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Description
Summary:Purpose To compare contrast sensitivity using a commercially available technique between patients with infantile nystagmus syndrome (INS) and controls. Design Prospective, comparative case series. Methods The functional acuity contrast test (FACT) was used binocularly in patients with INS and aged-matched controls with best acuity under normal lighting using a progression of high-quality sine wave grating size changes with increasing spatial frequencies. Results Nine INS patients aged 5 to 11 years and 25 controls were tested. The INS patients’ best binocular acuity ranged from 20/125 to 20/30, and that of the controls was 20/25 or better. When compared with age-matched controls, INS patients displayed deficiencies in contrast sensitivity syndrome using the FACT test. Conclusions The FACT or a similar testing system may have potential as a commercially available outcome measure in clinical trials in patients with INS.
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2007.02.028