Indicators of poor prognosis of acute pericarditis

• Published in: Circulation (New York, N.Y.) N.Y.), 2007-05, Vol.115 (21), p.2739-2744
• Main Authors: IMAZIO, Massimo, CECCHI, Enrico, DEMICHELIS, Brunella, IERNA, Salvatore, DEMARIE, Daniela, GHISIO, Aldo, POMARI, Franco, CODA, Luisella, BELLI, Riccardo, TRINCHERO, Rita
• Format: Article
• Language: English
• Subjects: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Blood and lymphatic vessels; Blood. Blood coagulation. Reticuloendothelial system; Cardiac Tamponade; Cardiology. Vascular system; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Drug Resistance; Female; Fever; Follow-Up Studies; Humans; Male; Medical sciences; Middle Aged; Multivariate Analysis; Neuropharmacology; Neuroprotective agent; Pericardial Effusion; Pericarditis - complications; Pericarditis - epidemiology; Pericarditis - etiology; Pharmacology. Drug treatments; Prognosis; Prospective Studies; Risk Factors
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/CIRCULATIONAHA.106.662114

The clinical search for indicators of poor prognosis of acute pericarditis may be useful for clinical triage of patients at high risk of specific causal conditions or complications. The aim of the present article is to assess the relationship between clinical features at presentation and specific causes or complications. A total of 453 patients aged 17 to 90 years (mean age 52+/-18 years, 245 men) with acute pericarditis (post-myocardial infarction pericarditis was excluded) were prospectively evaluated from January 1996 to August 2004. A specific cause was found in 76 of 453 patients (16.8%): autoimmune in 33 patients (7.3%), neoplastic in 23 patients (5.1%), tuberculous in 17 patients (3.8%), and purulent in 3 patients (0.7%). In multivariable analysis, women (hazard ratio [HR] 1.67, 95% confidence interval [CI] 1.03 to 2.70; P=0.036) and patients with fever >38 degrees C (HR 3.56, 95% CI 1.82 to 6.95; P