Capillary filtration is reduced in lungs adapted to chronic heart failure : morphological and haemodynamic correlates

• Published in: Cardiovascular research 2001, Vol.49 (1), p.207-217
• Main Authors: WENXIN HUANG, KINGSBURY, Martyn P, TURNER, Mark A, DONNELLY, J. Leo, FLORES, Nicholas A, SHERIDAN, Desmond J
• Format: Article
• Language: English
• Subjects: Adaptation, Physiological; Animals; Biological and medical sciences; Body Water; Capillary Permeability - physiology; Cardiology. Vascular system; Guinea Pigs; Heart; Heart Failure - pathology; Heart Failure - physiopathology; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Hemodynamics - physiology; Lung - blood supply; Lung - pathology; Male; Medical sciences; Myocardium - pathology; Organ Size; Pulmonary Circulation - physiology; Vascular Resistance - physiology
• ISSN: 0008-6363; 1755-3245
• DOI: 10.1016/s0008-6363(00)00223-6

To determine pulmonary capillary filtration in experimental chronic heart failure and to investigate some morphological and haemodynamic mechanisms that could account for reduced filtration in lungs adapted to chronic heart failure. We studied pulmonary capillary filtration, vascular resistances and morphology in lungs from guinea-pigs adapted to chronic heart failure. Heart failure was induced by banding of the ascending aorta (n=66) or sham control operation (n=78) in guinea-pigs which were studied at 150+/-8 days post-operation. Reduced cardiac output, increased systemic vascular resistance and LV end diastolic pressure and increased LV and RV weight:body weight ratio (all P