Oxidative stress: the effect of erythropoietin and the dialysis membrane

Dialysis patients run the risk of impaired antioxidative defense and increased free radicals (FR) production. The study was made in order to compare FR-related parameters in ten patients treated with erythropoietin (EPO+) and ten patients not subject to this treatment (EPO-). All patients showed sta...

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Bibliographic Details
Published in:International journal of artificial organs 2000-01, Vol.23 (1), p.33-40
Main Authors: Eiselt, J, Racek, J, Opatrný, Jr, K
Format: Article
Language:English
Subjects:
Adult
Aged
Anemia - drug therapy
Anemia - etiology
Antioxidants - analysis
Erythropoietin - therapeutic use
Female
Free Radicals
Humans
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - therapy
Male
Membranes, Artificial
Middle Aged
Oxidative Stress - physiology
Renal Dialysis - adverse effects
Treatment Outcome
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Summary:Dialysis patients run the risk of impaired antioxidative defense and increased free radicals (FR) production. The study was made in order to compare FR-related parameters in ten patients treated with erythropoietin (EPO+) and ten patients not subject to this treatment (EPO-). All patients showed stable hemoglobin levels at > 95 g/L. FR-related parameters were monitored during hemodialysis (HD) using a polysulfon (PS) or a hemophan (H) membrane for 12 of them (6 EPO+ a 6 EPO-). The EPO- group was found to have a higher activity of superoxide dismutase (SOD, 1160 + 218 vs; 882 + 125 IU/gHb, p
ISSN:0391-3988
1724-6040
DOI:10.1177/039139880002300106