Time-Dependent Variations in Urine Output After Renal Transplantation

• Published in: Transplantation proceedings 2007-05, Vol.39 (4), p.932-933
• Main Authors: Khosroshahi, H.T, Oskui, R, Shoja, M.M, Tubbs, R.S, Ardalan, M.R
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Circadian Rhythm; Creatinine - blood; Cross-Sectional Studies; Diuresis - physiology; Female; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Kidney Transplantation - physiology; Living Donors; Male; Medical sciences; Patient Selection; Prospective Studies; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system; Time Factors; Tissue, organ and graft immunology
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2007.04.006

Abstract Introduction Diuresis begins soon after renal transplantation. Although controversial, early post kidney transplant urine volume may correlate with favorable short- and long-term allograft survival. The aim of the present study was to examine the potential changes in urine volume within the first 6 months after renal transplantation. Methods In a prospective study, the first month serum creatinine level and daily urine volume were measured at 24 and 48 hours, and at 1 month after renal transplantation in patients with stable kidney function without the evidence of allograft rejection ( n = 54). Fifteen patients were also followed for their urine output at least 6 months post kidney transplantation. Data are expressed in mean values ± SD. Statistical analysis was performed by SPSS version 13.0 using ANOVA. Correlation between continuous variables was performed using the Pearson test. The P value was set at .05. Results The mean age of the renal allograft recipients was 35.5 ± 12.1 years with a male to female ratio of ∼1.3. The mean first month serum creatinine was 1.26 ± 0.4 mg/dL. The mean urine outputs were 10.06 ± 5.89, 5.45 ± 3.05, and 3.44 ± 1.25 L at 24 and 48 hours and 1 month post renal transplantation. Those patients who were followed for 6 months post transplant ( n = 15) were observed to have a mean urine volume of 3.20 ± 1.24 L at the end of this period. This trend showed that urine volume steadily decreased from 24 and 48 hours to 1 month after renal transplantation ( P < .05). However, urine volumes were rather comparable at one month and 6 months after transplantation ( P > .05). A positive correlation was found between the first-month serum creatinine and the urine volume at one month ( r = 0.302 and P = .035). Conclusion Although urine volume showed considerable variation early after renal transplantation, it stabilized by 1 month after transplantation, which was also positively correlated with the first-month serum creatinine. Moreover, we concluded that in stable patients, the final urine output was related to early graft function.