Acute and chronic complications of type 2 diabetes mellitus in children and adolescents

Summary With the increase in prevalence of type 2 diabetes mellitus in adolescents, a rise in incidence of secondary comorbidities—including hypertension, hyperlipidaemia, nephropathy, and retinopathy—is anticipated. Furthermore, findings of studies in young adults have suggested that the developmen...

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Bibliographic Details
Published in:The Lancet (British edition) 2007-05, Vol.369 (9575), p.1823-1831
Main Authors: Pinhas-Hamiel, Orit, Dr, Zeitler, Philip, MD
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adolescents
Adults
African Americans
Biological and medical sciences
Child
Children
Children & youth
Chronic Disease
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 2 - complications
Diabetes. Impaired glucose tolerance
Diabetic Ketoacidosis - epidemiology
Diabetic Ketoacidosis - mortality
Dyslipidemias - complications
Dyslipidemias - epidemiology
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Epidemiology
Etiopathogenesis. Screening. Investigations. Target tissue resistance
General aspects
Health risk assessment
Humans
Hypercholesterolemia - complications
Hypercholesterolemia - epidemiology
Hyperlipidemia
Hypertension
Internal Medicine
Medical sciences
Morbidity
Mortality
Natural history
Nephropathy
Obesity
Prevalence
Public health
Retinopathy
Studies
Teenagers
Young adults
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Summary:Summary With the increase in prevalence of type 2 diabetes mellitus in adolescents, a rise in incidence of secondary comorbidities—including hypertension, hyperlipidaemia, nephropathy, and retinopathy—is anticipated. Furthermore, findings of studies in young adults have suggested that the development and progression of clinical complications might be especially rapid when the onset of type 2 diabetes is early, raising the possibility of a serious public-health challenge in the next few decades. To date, reports of the epidemiology and natural history of secondary complications specifically in adolescents with type 2 diabetes have been scarce. Yet, we must begin to understand the extent of the coming challenge. To this end, we have reviewed reports on acute and long-term comorbidities associated with type 2 diabetes in young people and have looked at mounting evidence that this group could be at increased risk for development of early complications.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(07)60821-6