Black Tea Improves Endothelial Function in Renal Transplant Recipients

• Published in: Transplantation proceedings 2007-05, Vol.39 (4), p.1139-1142
• Main Authors: Ardalan, M.R, Tarzamni, M.K, Shoja, M.M, Tubbs, R.S, Rahimi-Ardabili, B, Ghabili, K, Khosroshahi, H.T
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Brachial Artery; Endothelium, Vascular - physiology; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Kidney Transplantation - physiology; Male; Medical sciences; Middle Aged; Patient Selection; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tea - physiology; Tissue, organ and graft immunology; Transplantation, Homologous; Vasodilation - physiology
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2007.04.010

Abstract Background Endothelial damage and dysfunction are commonplace in renal transplant recipients. Impaired endothelial function is an important contributor to cardiovascular diseases. We hypothesized that short-term black tea consumption may improve endothelium-dependent arterial dilation in kidney recipients. Methods Fifteen recipients were studied on an outpatient basis in a single, university-affiliated clinic. Inclusion criteria were stable and good allograft function. The main exclusion criteria were uncontrolled hypertension, smoking, alcohol consumption, coffee drinking, diabetes mellitus, and coronary artery disease, or a history of upper limb vascular manipulations. After overnight fasting, the brachial artery diameter (BAD) was measured at the end of diastole using an ultrasound machine before (basal BAD) and 1 minute after temporary (∼3 minutes) external occlusion (posthyperemia BAD). Flow-mediated vasodilation (FMV) and percent of FMV (FMV%) were calculated by appropriate formula. FMV and FMV% were determined at baseline and 2 hours after consuming 0.5 L freshly brewed black tea. For control, the study was repeated for each patient the next day and FMV and FMV% were determined before and 2 hours after consuming 0.5 L of water. Results The men age of patients was 37.2 ± 9.7 years (range, 25 to 50) with a male:female ratio of 3:2. Patients were 26.8 ± 10.6 months postrenal transplantation. Black tea consumption significantly increased posthyperemia BAD, FMV, and FMV% ( P < .05). However, water consumption did not alter the basal or posthyperemia BAD, FMV, or FMV% ( P > .05). Conclusion Based on our study, short-term consumption of black tea may improve endothelial function and endothelium-dependent arterial vasodilation in renal transplant recipients.