Effects of different types of fluid shear stress on endothelial cell proliferation and survival

We attempted to clarify the effect of different types of shear stress on endothelial cell (EC) proliferation and survival. Bovine aortic ECs were subjected to either steady laminar, 1 Hz pulsatile, or 1 Hz to and fro shear at 14 dyne/cm2. % of BrdU positive EC was 14.3 ± 1.6% in steady, 21.5 ± 3.2%...

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Bibliographic Details
Published in:Journal of cellular physiology 2007-07, Vol.212 (1), p.244-251
Main Authors: Kadohama, Takayuki, Nishimura, Kengo, Hoshino, Yuji, Sasajima, Tadahiro, Sumpio, Bauer E.
Format: Article
Language:English
Subjects:
Animals
Apoptosis - physiology
Biomechanical Phenomena
Carrier Proteins - metabolism
Cattle
Cell Proliferation
Cell Survival - physiology
Endothelial Cells - cytology
Endothelial Cells - physiology
Mitogen-Activated Protein Kinase 1 - metabolism
Mitogen-Activated Protein Kinase 3 - metabolism
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Summary:We attempted to clarify the effect of different types of shear stress on endothelial cell (EC) proliferation and survival. Bovine aortic ECs were subjected to either steady laminar, 1 Hz pulsatile, or 1 Hz to and fro shear at 14 dyne/cm2. % of BrdU positive EC was 14.3 ± 1.6% in steady, 21.5 ± 3.2% in pulsatile, and 11.4 ± 2.4% in to and fro after 4 h, respectively (P 
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.21024