Platelet function and antiplatelet therapy

Background: Platelets have roles other than haemostasis and many are relevant to surgical practice. This review examines both the pathophysiology of platelets in haemostasis and thrombosis, and other roles of clinical importance. Methods: A literature review of the various functional roles of platel...

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Bibliographic Details
Published in:British journal of surgery 2007-06, Vol.94 (6), p.674-682
Main Authors: Troxler, M., Dickinson, K., Homer-Vanniasinkam, S.
Format: Article
Language:English
Subjects:
Atherosclerosis - blood
Atherosclerosis - drug therapy
Atherosclerosis - physiopathology
Biological and medical sciences
Blood Platelets - drug effects
Blood Platelets - pathology
Blood Platelets - physiology
General aspects
Hemostasis - physiology
Humans
Inflammatory Bowel Diseases - blood
Inflammatory Bowel Diseases - drug therapy
Inflammatory Bowel Diseases - physiopathology
Medical sciences
Neoplasm Metastasis
Neoplasms - blood
Neoplasms - drug therapy
Neoplasms - physiopathology
Platelet Aggregation Inhibitors - pharmacology
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Summary:Background: Platelets have roles other than haemostasis and many are relevant to surgical practice. This review examines both the pathophysiology of platelets in haemostasis and thrombosis, and other roles of clinical importance. Methods: A literature review of the various functional roles of platelets was performed (Medline search, English language) including their action in inflammation (in particular in atherothrombosis), antimicrobial defence and tumour growth. Current clinical evidence for antiplatelet therapy is also reviewed. Results and conclusion: Platelet functions are multiple, complex and not limited to haemostasis. Understanding of platelet pathophysiology continues to grow and this is relevant to many aspects of surgical practice, particularly the clinical use of antiplatelet therapy. Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. Not limited to thrombosis
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.5852