Intratumour heterogeneity in microvessel oxyhaemoglobin saturations

The aim of the present study was to examine intratumour heterogeneity in microvessel oxyhaemoglobin (HbO2) saturations in human melanoma xenografts. The HbO2 saturations, measured with a cryospectrophotometric micromethod, were found to vary substantially within single tumours. All tumours showed a...

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 2001-01, Vol.162 (2), p.245-251
Main Authors: MASEIDE, Karstein, ROFSTAD, Einar K
Format: Article
Language:English
Subjects:
Animal tumors. Experimental tumors
Animals
Biological and medical sciences
Experimental skin tumors
Female
Humans
Medical sciences
Melanoma - blood supply
Melanoma - metabolism
Mice
Mice, Inbred BALB C
Neoplasm Transplantation
Oxyhemoglobins - metabolism
Spectrophotometry
Transplantation, Heterologous
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of the present study was to examine intratumour heterogeneity in microvessel oxyhaemoglobin (HbO2) saturations in human melanoma xenografts. The HbO2 saturations, measured with a cryospectrophotometric micromethod, were found to vary substantially within single tumours. All tumours showed a decrease in overall HbO2 saturation from the periphery towards the centre, although the profiles could vary substantially between individual tumours. Local differences could be large, and many tumours had HbO2 saturations spanning from 0 to 100% in peripheral regions. In central tumour regions, low saturations were prevailing although subregions of intermediate and high saturations could also be found.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(00)00670-4