Misregistration artifacts in image-derived arterial input function in non-echo-planar imaging-based dynamic contrast-enhanced MRI

Purpose To characterize misregistration artifact in arterial input function (AIF) pixels in dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) using a two‐dimensional non‐echo‐planar imaging (EPI)‐based gradient‐recalled echo (GRE) sequence. Materials and Methods Dynamic gadopentetate‐en...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2007-06, Vol.25 (6), p.1248-1255
Main Authors: Kuribayashi, Hideto, Worthington, Philip L., Bradley, Daniel P., Checkley, David R., Tessier, Jean J., Waterton, John C.
Format: Article
Language:English
Subjects:
Abdomen - anatomy & histology
Animals
Aorta, Abdominal - anatomy & histology
arterial input function
Computer Simulation
Contrast Media - administration & dosage
dynamic contrast-enhanced magnetic resonance imaging
Gadolinium DTPA - administration & dosage
Image Processing, Computer-Assisted
Magnetic Resonance Imaging - methods
misregistration artifact
phase shift
Rats
semikeyhole
sliding-window reconstruction
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Summary:Purpose To characterize misregistration artifact in arterial input function (AIF) pixels in dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) using a two‐dimensional non‐echo‐planar imaging (EPI)‐based gradient‐recalled echo (GRE) sequence. Materials and Methods Dynamic gadopentetate‐enhanced MRI was acquired in the rat using a semikeyhole acquisition scheme. The AIF was obtained from abdominal aorta pixels. Different sliding‐window reconstruction techniques were applied to determine which lines in a series of the semikeyhole acquisition were associated with the misregistration artifacts. Results The misregistration along the phase‐encoding direction arose when k‐space lines were acquired during the rise‐time of the aortic gadolinium concentration. The maximum blood concentration of gadolinium estimated from the phase shift calculation agreed with that estimated from dosage. Conclusion AIF misregistration results from a phase shift due to increasing gadolinium concentration in the aorta, and may need to be considered in small animal DCE‐MRI studies with a high rate of rise in the AIF in high‐field MR applications. J. Magn. Reson. Imaging 2007;25:1248–1255. © 2007 Wiley‐Liss, Inc.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.20924