Anthraquinones from the stem bark of Stereospermum zenkeri with antimicrobial activity

• Published in: Phytochemistry (Oxford) 2007-06, Vol.68 (11), p.1595-1599
• Main Authors: Lenta, Bruno N., Weniger, Bernard, Antheaume, Cyril, Noungoue, Diderot T., Ngouela, Silvère, Assob, Jules C.N., Vonthron-Sénécheau, Catherine, Fokou, Patrice A., Devkota, Krishna P., Tsamo, Etienne, Sewald, Norbert
• Format: Article
• Language: English
• Subjects: anthraquinones; Anthraquinones - chemistry; Anthraquinones - isolation & purification; Anthraquinones - pharmacology; Anti-Infective Agents - chemistry; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; antibacterial properties; Antimicrobial; Bignoniaceae; Bignoniaceae - chemistry; Biological and medical sciences; Chemical constitution; chemical structure; Coumaric Acids - chemistry; Coumaric Acids - isolation & purification; Coumaric Acids - pharmacology; Fundamental and applied biological sciences. Psychology; General pharmacology; Glucosides - chemistry; Glucosides - isolation & purification; Glucosides - pharmacology; human health; Medical sciences; medicinal plants; Microbial Sensitivity Tests; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; phytochemicals; Plant Bark - chemistry; Plant physiology and development; Propionates; Pseudomonas aeruginosa - drug effects; Sitosterols - chemistry; Sitosterols - isolation & purification; Sitosterols - pharmacology; spectral analysis; stereochemistry; Stereospermum; Stereospermum zenkeri; traditional medicine; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenes - pharmacology; zenkequinone; Zenkequinones A and B
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2007.03.037

Two anthraquinones 1 and 2 were isolated from Stereospermum zenkeri and compound 2 showed the best antimicrobial activity (MIC 9.50 μg/ml) against gram-negative Pseudomonas aeruginosa. Two anthraquinones, zenkequinones A and B were isolated from the stem bark of Stereospermum zenkeri together with known sterequinone-F, p-coumaric acid, sitosterol-3-O-β- d-glucopyranoside and 3β-hydroxyolean-12-en-28-O-β- d-glucopyranoside. Their structures were established by spectroscopic methods. The antimicrobial activity of the isolated compounds was evaluated against six multiresistant strains of pathogens. Zenkequinone B showed the best antibacterial activity (MIC 9.50 μg/ml) against gram-negative Pseudomonas aeruginosa.