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Studies on synthesis and pharmacological activities of 3,6-disubstituted-1,2,4-triazolo[3,4- b]-1,3,4-thiadiazoles and their dihydro analogues

Several 3,6-disubstituted-1,2,4-triazolo[3,4- b]-1,3,4-thiadiazole and their dihydro analogues were synthesized from hetero aromatic acids and hetero aromatic aldehydes, respectively, by microwave-assisted dry media and conventional methods. Elemental analysis, IR, 1H NMR, 13C NMR and mass spectral...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2007-06, Vol.42 (6), p.823-840
Main Authors: Mathew, Vinod, Keshavayya, J., Vaidya, V.P., Giles, D.
Format: Article
Language:English
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Summary:Several 3,6-disubstituted-1,2,4-triazolo[3,4- b]-1,3,4-thiadiazole and their dihydro analogues were synthesized from hetero aromatic acids and hetero aromatic aldehydes, respectively, by microwave-assisted dry media and conventional methods. Elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data elucidated the structures of all newly synthesized compounds. Synthesized compounds are studied for their antibacterial, antifungal, anti-inflammatory and analgesic activities. Some of the tested compounds showed significant pharmacological activities. [Display omitted] A series of 3,6-disubstituted 1,2,4-triazolo[3,4- b]-thiadiazoles and their dihydro analogues were synthesized by microwave-assisted and conventional methods. The above compounds were studied for their antibacterial, antifungal, anti-inflammatory and analgesic activities.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2006.12.010