Studies on synthesis and pharmacological activities of 3,6-disubstituted-1,2,4-triazolo[3,4- b]-1,3,4-thiadiazoles and their dihydro analogues

Several 3,6-disubstituted-1,2,4-triazolo[3,4- b]-1,3,4-thiadiazole and their dihydro analogues were synthesized from hetero aromatic acids and hetero aromatic aldehydes, respectively, by microwave-assisted dry media and conventional methods. Elemental analysis, IR, 1H NMR, 13C NMR and mass spectral...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2007-06, Vol.42 (6), p.823-840
Main Authors: Mathew, Vinod, Keshavayya, J., Vaidya, V.P., Giles, D.
Format: Article
Language:English
Subjects:
Amino triazoles
Analgesics
Analgesics - chemistry
Analgesics - pharmacology
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Dihydro triazolo thiadiazoles
Female
Fungi - drug effects
General aspects
Male
Medical sciences
Mice
Microwave synthesis
Molecular Structure
Neuropharmacology
Pharmacology. Drug treatments
Phosphorous oxychloride
Rats
Rats, Wistar
Structure-Activity Relationship
Thiadiazoles - chemistry
Thiadiazoles - pharmacology
Triazolo thiadiazoles
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Summary:Several 3,6-disubstituted-1,2,4-triazolo[3,4- b]-1,3,4-thiadiazole and their dihydro analogues were synthesized from hetero aromatic acids and hetero aromatic aldehydes, respectively, by microwave-assisted dry media and conventional methods. Elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data elucidated the structures of all newly synthesized compounds. Synthesized compounds are studied for their antibacterial, antifungal, anti-inflammatory and analgesic activities. Some of the tested compounds showed significant pharmacological activities. [Display omitted] A series of 3,6-disubstituted 1,2,4-triazolo[3,4- b]-thiadiazoles and their dihydro analogues were synthesized by microwave-assisted and conventional methods. The above compounds were studied for their antibacterial, antifungal, anti-inflammatory and analgesic activities.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2006.12.010