The LDL receptor is the major pathway for β-VLDL uptake by mouse peritoneal macrophages

In order to determine the contribution of the low density lipoprotein receptor (LDL-R) to the removal of apoB-containing native lipoproteins by macrophages, we compared the uptake of β-VLDL in peritoneal macrophages (MPM) from wild type mice and mice lacking the LDL-R. The d

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Bibliographic Details
Published in:Atherosclerosis 2001, Vol.154 (1), p.51-60
Main Authors: Perrey, Stéphane, Ishibashi, Shun, Kitamine, Tetsuya, Osuga, Jun-ichi, Yagyu, Hiroaki, Chen, Zhong, Shionoiri, Futoshi, Iizuka, Yoko, Yahagi, Naoya, Tamura, Yoshiaki, Ohashi, Ken, Harada, Kenji, Gotoda, Takanari, Yamada, Nobuhiro
Format: Article
Language:English
Subjects:
Animals
Apolipoproteins E - analysis
Apolipoproteins E - genetics
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cholesterol - metabolism
Cholesterol Esters - biosynthesis
Foam cell formation
Knock-out mice
Lipoproteins - metabolism
Lipoproteins, LDL - pharmacology
Lipoproteins, VLDL - chemistry
Lipoproteins, VLDL - metabolism
Lipoproteins, VLDL - pharmacology
Macrophages, Peritoneal - metabolism
Medical sciences
Mice
Mice, Transgenic - genetics
Receptor
Receptors, LDL - genetics
Receptors, LDL - metabolism
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Description
Summary:In order to determine the contribution of the low density lipoprotein receptor (LDL-R) to the removal of apoB-containing native lipoproteins by macrophages, we compared the uptake of β-VLDL in peritoneal macrophages (MPM) from wild type mice and mice lacking the LDL-R. The d
ISSN:0021-9150
1879-1484
DOI:10.1016/S0021-9150(00)00457-3