Time-courses of Fos expression in rat hippocampus and neocortex following acquisition and recall of a socially transmitted food preference

• Published in: Neurobiology of learning and memory 2007-07, Vol.88 (1), p.65-74
• Main Authors: Smith, Clayton A., Countryman, Renee A., Sahuque, Lacey L., Colombo, Paul J.
• Format: Article
• Language: English
• Subjects: Analysis of Variance; Animals; Association Learning - physiology; Behavioral psychophysiology; Biological and medical sciences; Brain research; c-Fos; Entorhinal Cortex - metabolism; Food Preferences - physiology; Food supply; Frontal Lobe - metabolism; Fundamental and applied biological sciences. Psychology; Gene expression; Hippocampus; Hippocampus - metabolism; Imitative Behavior - physiology; Male; Memory; Mental Recall - physiology; Neocortex; Neocortex - metabolism; Neurology; Orbitofrontal cortex; Prefrontal cortex; Prefrontal Cortex - metabolism; Proto-Oncogene Proteins c-fos - metabolism; Psychology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Long-Evans; Rodents; Social Behavior; Social transmission of food preference; Time Factors; Tissue Distribution
• ISSN: 1074-7427; 1095-9564
• DOI: 10.1016/j.nlm.2007.03.001

The present study examined expression of the immediate-early gene, c-Fos, following acquisition, 48-h (recent) recall, and 1-week (remote) recall of a socially transmitted food preference (STFP) in multiple brain regions implicated in learning and memory. In comparisons with controls, trained Long-Evans rats had increased Fos immunoreactivity in the ventral hippocampus following acquisition and recent recall. In the parahippocampal cortices, Fos was increased in the lateral entorhinal cortex after acquisition. In the orbitofrontal cortex, increased Fos immunoreactivity was observed in the lateral orbital cortex following both recent and remote recall and in the ventral orbital cortex following remote recall, indicating a role for the orbitofrontal cortex in the remote recall of STFP memory. In contrast, in the medial prefrontal cortex, increased Fos-ir was found following acquisition in the prelimbic cortex and following recent recall in the prelimbic and infralimbic cortices. No differences in Fos expression were found between trained rats and controls in the dorsal hippocampus, posterior parietal cortex, or amygdala. The present findings support a time-limited role of the hippocampus in the acquisition and recall of STFP memory and implicate neocortical regions involved in STFP acquisition, recent, and remote recall.