Significance of urine protein/creatinine ratio in pregnancy-induced hypertension

The present study was planned to compare random urine protein/creatinine [P:C] ratio PGIMS with 24 h urine protein excretion in 70 clinically diagnosed /suspected cases of hypertensive disorders of pregnancy in Department of Biochemistry and Obstetrics and Gynaecology, Rohtak. Seventy clinically dia...

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Bibliographic Details
Published in:Clinica chimica acta 2007-07, Vol.382 (1), p.145-147
Main Authors: Pahwa, Manju Bala, Seth, Shashi, Khosla, Anju
Format: Article
Language:English
Subjects:
Adolescent
Adult
Albuminuria - urine
Creatinine
Creatinine - urine
Female
Humans
Hypertension, Pregnancy-Induced - metabolism
Hypertension, Pregnancy-Induced - urine
PIH
Predictive Value of Tests
Pregnancy
Pregnancy Outcome
Proteinuria - metabolism
Proteinuria - urine
Urine protein
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Summary:The present study was planned to compare random urine protein/creatinine [P:C] ratio PGIMS with 24 h urine protein excretion in 70 clinically diagnosed /suspected cases of hypertensive disorders of pregnancy in Department of Biochemistry and Obstetrics and Gynaecology, Rohtak. Seventy clinically diagnosed/suspected cases of hypertensive pregnant women and sixty age matched healthy pregnant women were taken in this study. All women, patients [ n = 70] and controls [ n = 60], were analysed for random urine specimen for protein and creatinine levels and 24-h urine specimen for protein excretion. Urine protein was estimated by Biuret method and creatinine by end point Jaffe's method. 24-h urine protein excretion rate correlated with random urine protein/creatinine ratio with Pearson correlation single tailed. [SPSS-10.0 Statistical analyses packages]. No single protein/creatinine ratio cut off value was ideal to distinguish between significant and insignificant proteinuria, however ratio more than 30 mg/mmol creatinine[P:C < 0.5 ]was optimum. P:C ratio more than 0.5 required hospital intervention in these patients. It is concluded that a urine protein/creatinine ratio of a single voided urine specimen may provide an accurate, inexpensive and rapid method for quantitation of proteinuria in suspected hypertensive pregnant women within a matter of hours. It would improve clinical care and follow-up especially when managing these women as outpatients.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2007.03.022