Reversible posterior leukoencephalopathy syndrome in a patient with multiple system atrophy: A possible association with oral midodrine treatment

We describe a 51‐year‐old man with a 3‐year history of multiple system atrophy, who developed a reversible posterior leukoencephalopathy syndrome (RPLS) after receiving prescription midodrine for therapeutic treatment of orthostatic hypotension. Typical reversible magnetic resonance imaging findings...

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Bibliographic Details
Published in:Movement disorders 2007-05, Vol.22 (7), p.1043-1046
Main Authors: Kim, Joong-Seok, Lee, Kwang-Soo, Lim, Sung-Chul, Ahn, Jae-Young, Song, In-Uk, Kim, Yeong-In, Kim, Bum-Soo, Kim, Hee-Tae
Format: Article
Language:English
Subjects:
Adrenergic alpha-Agonists - therapeutic use
Biological and medical sciences
Brain - drug effects
Brain - pathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia, Vascular - complications
Dementia, Vascular - drug therapy
Dementia, Vascular - pathology
Humans
Magnetic Resonance Imaging - methods
Male
Medical sciences
Middle Aged
midodrine
Midodrine - therapeutic use
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
multiple system atrophy
Multiple System Atrophy - complications
Multiple System Atrophy - drug therapy
Neurology
orthostatic hypotension
reversible posterior leukoencephalopathy syndrome
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Summary:We describe a 51‐year‐old man with a 3‐year history of multiple system atrophy, who developed a reversible posterior leukoencephalopathy syndrome (RPLS) after receiving prescription midodrine for therapeutic treatment of orthostatic hypotension. Typical reversible magnetic resonance imaging findings, following treatment with midodrine, suggested a possible relationship between midodrine treatment, supine hypertension, and RPLS, although a cause‐and‐effect relationship cannot be confirmed. © 2007 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.21461