Subacute postictal aggression in patients with epilepsy

Abstract Three men with epilepsy (age range, 38–62) who exhibited brief episodes of violent behavior during the postictal period are described. Disease duration ranged from 27 to 44 years. Patients had both complex partial seizures and secondarily generalized tonic–clonic seizures, which were refrac...

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Bibliographic Details
Published in:Epilepsy & behavior 2007-06, Vol.10 (4), p.611-614
Main Authors: Ito, Masumi, Okazaki, Mitsutoshi, Takahashi, Sho, Muramatsu, Reimi, Kato, Masaaki, Onuma, Teiichi
Format: Article
Language:English
Subjects:
Adult
Aggression - psychology
Cerebrovascular Circulation - physiology
Disease duration
Electroencephalography
Epilepsy
Epilepsy, Complex Partial - complications
Epilepsy, Complex Partial - psychology
Epilepsy, Generalized - complications
Epilepsy, Generalized - psychology
Epilepsy, Tonic-Clonic - complications
Epilepsy, Tonic-Clonic - psychology
Frontal lobe
Generalized tonic–clonic seizure
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neurologic Examination
Neurology
Neuropsychological Tests
Postictal aggression
Postictal psychosis
Seizures - complications
Seizures - psychology
Temporal lobe
Tomography, Emission-Computed, Single-Photon
Violent behavior
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Summary:Abstract Three men with epilepsy (age range, 38–62) who exhibited brief episodes of violent behavior during the postictal period are described. Disease duration ranged from 27 to 44 years. Patients had both complex partial seizures and secondarily generalized tonic–clonic seizures, which were refractory to antiepileptic drugs. Postictal aggression occurred shortly after a seizure and lasted 5–30 minutes. The patients displayed physically and verbally aggressive behavior toward others, but regained consciousness promptly and showed regret afterward. Interictal EEGs revealed temporal spikes, SPECT showed hypoperfusion in the temporal and frontal areas in two patients, and neuropsychological examination revealed poor frontal lobe function in two patients. Characteristics of our cases are consistent with subacute postictal aggression (SPA) reported previously. Epilepsy of prolonged duration and brain dysfunction involving a broad area including the temporal and frontal lobes may be associated with the occurrence of subacute postictal aggression.
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2007.02.016