Anti-oxidation and immune responses in mice upon exposure to manganese superoxide dismutase expressed in silkworm larvae, Bombyx mori L

With manganese superoxide dismutase expressed in silkworm larvae, Bomby mori L, we investigate the effects of silkworm larvae powder containing SOD on the antioxidation and the immune system of mouse. The contents of MDA both in mice plasma or liver organ treated with silkworm larvae powder containi...

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Bibliographic Details
Published in:Cell biology international 2007-09, Vol.31 (9), p.974-978
Main Authors: Yue, Wan-Fu, Li, Guang-Li, Liu, Jian-Mei, Sun, Jian-Tong, Sun, Hong-Xiang, Li, Xing-Hua, Wu, Xiao-Feng, Miao, Yun-Gen
Format: Article
Language:English
Subjects:
Animals
Anti-oxidation
Bombyx - enzymology
Cell Death
Erythrocytes - metabolism
Hemagglutination
Hemolysin Proteins - blood
Immunity
Killer Cells, Natural - cytology
Larva - enzymology
Liver Extracts
Male
Manganese superoxide dismutase (SOD)
Mice
Mice, Inbred ICR
Mouse
Oxidation-Reduction
Sheep
Silkworm ( Bombyx mori L.)
Superoxide Dismutase - immunology
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Summary:With manganese superoxide dismutase expressed in silkworm larvae, Bomby mori L, we investigate the effects of silkworm larvae powder containing SOD on the antioxidation and the immune system of mouse. The contents of MDA both in mice plasma or liver organ treated with silkworm larvae powder containing manganese superoxide dismutase were reduced compare to control. The superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities both in plasma or liver organ of the treated mice were significantly higher than that of both control and bromobenzene treated mice (group-BM), suggesting the silkworm larvae powder containing SOD play a positive role in anti-oxidation in mice. This experiment was also designed to investigate the effects of silkworm larvae powder containing SOD on the immune system of mouse, focused on hemolysin response, hemagglutination against SRBC and the activity of natural killer (NK) cells. All treated mice showed significant increase in hemolysin response to SRBC and demonstrated an activation of NK cell function by the SOD-contained silkworm larvae powder, which suggest a promotion in humoral immunity. The results suggested the SOD expressed in silkworm maybe have potential application in medicine.
ISSN:1065-6995
1095-8355
DOI:10.1016/j.cellbi.2007.03.007