Ameloblastic carcinoma: An analysis of 14 cases

Objectives To present the classifications of malignant ameloblastomas, provide histopathologic guidelines for the diagnosis of ameloblastic carcinoma, and discuss treatment and long-term follow-up. Study design Fourteen archival specimens of ameloblastic carcinoma with detailed treatment and follow-...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2007-06, Vol.103 (6), p.799-807
Main Authors: Hall, James M., DDS, Weathers, Dwight R., DDS, MSD, Unni, K. Krishnan, MB, BS
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Child
Dentistry
Female
Humans
Male
Mandibular Neoplasms - pathology
Mandibular Neoplasms - radiotherapy
Mandibular Neoplasms - surgery
Maxillary Neoplasms - pathology
Maxillary Neoplasms - radiotherapy
Maxillary Neoplasms - surgery
Medical sciences
Middle Aged
Neoplasm Recurrence, Local
Odontogenic Tumors - pathology
Odontogenic Tumors - radiotherapy
Odontogenic Tumors - surgery
Otorhinolaryngology. Stomatology
Retrospective Studies
Surgery
Treatment Outcome
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Summary:Objectives To present the classifications of malignant ameloblastomas, provide histopathologic guidelines for the diagnosis of ameloblastic carcinoma, and discuss treatment and long-term follow-up. Study design Fourteen archival specimens of ameloblastic carcinoma with detailed treatment and follow-up documentation were identified by the authors. Results Traditional methods of microscopic observation form the basis for diagnosis. Histopathologic features of ameloblastic carcinoma include lack of differentiation, hypercellularity, high mitotic index, vascular invasion, and neural invasion. Conclusion The long-term follow-up findings in this study support the concept that aggressive surgical intervention provides the best chance for survival. Patients treated otherwise had recurrence. The patients with the highest number of recurrences did not survive the disease.
ISSN:1079-2104
1528-395X
DOI:10.1016/j.tripleo.2006.11.048