Gene-environment interaction and the GNB3 gene in the Atherosclerosis Risk in Communities Study

• Published in: International Journal of Obesity 2007-06, Vol.31 (6), p.919-926
• Main Authors: Grove, M.L, Morrison, A, Folsom, A.R, Boerwinkle, E, Hoelscher, D.M, Bray, M.S
• Format: Article
• Language: English
• Subjects: Adult; adults; African Americans; Aged; alleles; Atherosclerosis; Atherosclerosis (general aspects, experimental research); Atherosclerosis - epidemiology; Atherosclerosis - genetics; Atherosclerosis Risk in Communities Study; Biological and medical sciences; Blacks; Blood and lymphatic vessels; Blood pressure; Cardiology. Vascular system; Cardiovascular disease; Care and treatment; Cohort Studies; Diabetes; disease prevalence; Epidemiology; ethnic differences; Exercise; Exercise - physiology; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; G proteins; Gene Frequency - genetics; genes; Genetic aspects; Genetic effects; Genetic polymorphisms; genetic variation; Genetics; Genotype; genotype-environment interaction; Genotype-environment interactions; Health Promotion and Disease Prevention; Heterotrimeric GTP-Binding Proteins - genetics; homozygosity; Humans; Hypertension; Hypertension - epidemiology; Hypertension - ethnology; Hypertension - genetics; Internal Medicine; Male; Medical sciences; Medicine; Medicine & Public Health; men; Metabolic Diseases; Middle Aged; Minority & ethnic groups; Nutrition research; Obesity; Obesity - epidemiology; Obesity - ethnology; Obesity - genetics; original-article; Pediatrics; physical activity; Physical fitness; Physiological aspects; Polymorphism; Polymorphism, Genetic - genetics; Prevalence; Protein Subunits - genetics; Proteins; Public Health; Research methodology; Research methods; Risk Factors; Smoking; Transient ischemic attack; United States - epidemiology; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Whites; women
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/sj.ijo.0803545

Objective: The purpose of this study was to investigate the interaction between the G-protein beta-3 (GNB3) 825C>T polymorphism and physical activity in relation to prevalent obesity and hypertension. Research methods and procedures: The GNB3 825C>T genotype was measured in a sample of 14 716 African Americans (AAs) and whites from the Atherosclerosis Risk in Communities (ARIC) study, and logistic regression was used to test for genetic effects and gene-environment interactions. Results: The GNB3 825C>T variant was not independently associated with prevalent obesity or hypertension in either AA or whites. However, we observed a significant interaction (PT polymorphism, obesity status and physical activity in predicting hypertension in the AA subjects. AA homozygotes for the 825T allele who were both obese and had a low activity level were 2.7 times more likely to be hypertensive, compared to non-obese, active 825C homozygotes (OR=2.71, 95% CI=1.19-6.17, PT variant may influence hypertension prevalence in AAs.