Selective Growth of a Stable Drug Polymorph by Suppressing the Nucleation of Corresponding Metastable Polymorphs

To stick or not to stick? Metastable (α) and stable (γ) polymorphs of indomethacin crystallize concomitantly from ethanol solutions. Crystallization in glass vials functionalized with perfluoroalkyl‐terminated silane monolayers, however, leads to the exclusive growth of the stable polymorph. These m...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2007-01, Vol.46 (23), p.4333-4336
Main Authors: Cox, Jason R., Ferris, Lori A., Thalladi, Venkat R.
Format: Article
Language:English
Subjects:
Chemistry, Pharmaceutical - methods
crystal growth
Crystallization
Indomethacin - chemistry
Molecular Structure
monolayers
nonstick surface
nucleation
Particle Size
Pharmaceutical Preparations - chemistry
polymorphism
Silanes - chemistry
Surface Properties
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Summary:To stick or not to stick? Metastable (α) and stable (γ) polymorphs of indomethacin crystallize concomitantly from ethanol solutions. Crystallization in glass vials functionalized with perfluoroalkyl‐terminated silane monolayers, however, leads to the exclusive growth of the stable polymorph. These monolayers create surfaces that inhibit the heterogeneous nucleation of α polymorph and thereby promote the growth of γ polymorph.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200605257