B-cell : a logical target for treatment of rheumatoid arthritis

The interest for B-cells in rheumatoid arthritis (RA) is currently being revived. They are involved in the development and activation of lymphoid architecture by regulating dentritic cell and T-cell function through cytokine production. Receptor editing an revising are also essential in B-cells and...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2007-03, Vol.25 (2), p.318-328
Main Authors: YOUINOU, P, JAMIN, C, SARAUX, A
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal - immunology
Antibodies, Monoclonal - pharmacology
Antibodies, Monoclonal - therapeutic use
Antibodies, Monoclonal, Murine-Derived
Antigens, CD20 - immunology
Antirheumatic Agents - pharmacology
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - immunology
Autoimmune Diseases - immunology
B-Lymphocytes - drug effects
B-Lymphocytes - immunology
B-Lymphocytes - pathology
Biological and medical sciences
CD5 Antigens - physiology
Cell Survival - physiology
Diseases of the osteoarticular system
Humans
Immunomodulators
Inflammatory joint diseases
Medical sciences
Pharmacology. Drug treatments
Rituximab
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Summary:The interest for B-cells in rheumatoid arthritis (RA) is currently being revived. They are involved in the development and activation of lymphoid architecture by regulating dentritic cell and T-cell function through cytokine production. Receptor editing an revising are also essential in B-cells and aid in preventing autoimmunity. Abnormalities in the subset distribution and a default in any task assigned to the B-cells may favor autoimmunity. Beneficied responses to B-cell depletion in RA by anti-CD20 monoclonal antibody rituximab illustrate the importance of B-lymphocytes in the pathogenesis of this disease. A new avenue has thus been opened, whereby B-lymphocytes return as a significant contributor to autoimmune disorders.
ISSN:0392-856X
1593-098X