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Effects of acute and chronic hypertension on the labyrinthine barriers in rat
Hearing loss, vertigo, and tinnitus have been related to arterial hypertension. The aim of the present work was to study the permeability of the blood-perilymph and of the labyrinthine barrier, between endolymph and perilymph, to small molecules during chronic and acute hypertension. Experiments wer...
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| Published in: | Hearing research 2001, Vol.151 (1-2), p.227-236 |
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| container_end_page | 236 |
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| container_title | Hearing research |
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| creator | MOSNIER, Isabelle TEIXEIRA, Marie LOISEAU, Alain FERNANDES, Isabelle STERKERS, Olivier AMIEL, Claude FERRARY, Evelyne |
| description | Hearing loss, vertigo, and tinnitus have been related to arterial hypertension. The aim of the present work was to study the permeability of the blood-perilymph and of the labyrinthine barrier, between endolymph and perilymph, to small molecules during chronic and acute hypertension. Experiments were performed in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Acute hypertension was induced by phenylephrine. Perilymph was sampled from the first turn of the scala vestibuli and the Na, K, urea, and radioactive concentrations ((14)C-urea and (3)H-mannitol) were measured. In another experimental set, the endocochlear potential was recorded from the basal turn of scala media, before and after phenylephrine injection. The composition of the perilymph and the kinetic constants for (14)C-urea and (3)H-mannitol were similar in WKY and SHR, and not modified after acute hypertension. In endolymph, the endocochlear potential in SHR (+80+/-2.7 mV, n=24) was lower (P |
| doi_str_mv | 10.1016/S0378-5955(00)00229-X |
| format | article |
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The aim of the present work was to study the permeability of the blood-perilymph and of the labyrinthine barrier, between endolymph and perilymph, to small molecules during chronic and acute hypertension. Experiments were performed in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Acute hypertension was induced by phenylephrine. Perilymph was sampled from the first turn of the scala vestibuli and the Na, K, urea, and radioactive concentrations ((14)C-urea and (3)H-mannitol) were measured. In another experimental set, the endocochlear potential was recorded from the basal turn of scala media, before and after phenylephrine injection. The composition of the perilymph and the kinetic constants for (14)C-urea and (3)H-mannitol were similar in WKY and SHR, and not modified after acute hypertension. In endolymph, the endocochlear potential in SHR (+80+/-2.7 mV, n=24) was lower (P<0.001) than in WKY (+98+/-1.5 mV, n=29). The endocochlear potential was decreased by 40 mV during acute hypertensive peak in seven out of 19 WKY but not in SHR rats (n=13). In conclusion, chronic or acute hypertension did not severely alter the permeability to small molecules of the blood-perilymph barrier. The relationship between the low endocochlear potential and hypertension in SHR remains to be evaluated. After acute hypertensive peak, the presence of vascular protective mechanisms in the cochlea could account for the stable endocochlear potential recorded in SHR and 60% of normotensive rats.</description><identifier>ISSN: 0378-5955</identifier><identifier>EISSN: 1878-5891</identifier><identifier>DOI: 10.1016/S0378-5955(00)00229-X</identifier><identifier>PMID: 11124468</identifier><identifier>CODEN: HERED3</identifier><language>eng</language><publisher>Amsterdam: Elsevier</publisher><subject>Acute Disease ; Animals ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Chronic Disease ; Cochlea - physiopathology ; Ear, Inner - physiopathology ; Endolymph - physiology ; Experimental diseases ; Hypertension - physiopathology ; Male ; Mannitol - cerebrospinal fluid ; Mannitol - pharmacokinetics ; Medical sciences ; Membrane Potentials ; Perilymph - physiology ; Permeability ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Urea - cerebrospinal fluid ; Urea - pharmacokinetics</subject><ispartof>Hearing research, 2001, Vol.151 (1-2), p.227-236</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c333t-b72d276f03a37776cd94ba71dab4d01f6ab732841644f0b6454a0c7520276103</citedby><cites>FETCH-LOGICAL-c333t-b72d276f03a37776cd94ba71dab4d01f6ab732841644f0b6454a0c7520276103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=997336$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11124468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MOSNIER, Isabelle</creatorcontrib><creatorcontrib>TEIXEIRA, Marie</creatorcontrib><creatorcontrib>LOISEAU, Alain</creatorcontrib><creatorcontrib>FERNANDES, Isabelle</creatorcontrib><creatorcontrib>STERKERS, Olivier</creatorcontrib><creatorcontrib>AMIEL, Claude</creatorcontrib><creatorcontrib>FERRARY, Evelyne</creatorcontrib><title>Effects of acute and chronic hypertension on the labyrinthine barriers in rat</title><title>Hearing research</title><addtitle>Hear Res</addtitle><description>Hearing loss, vertigo, and tinnitus have been related to arterial hypertension. The aim of the present work was to study the permeability of the blood-perilymph and of the labyrinthine barrier, between endolymph and perilymph, to small molecules during chronic and acute hypertension. Experiments were performed in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Acute hypertension was induced by phenylephrine. Perilymph was sampled from the first turn of the scala vestibuli and the Na, K, urea, and radioactive concentrations ((14)C-urea and (3)H-mannitol) were measured. In another experimental set, the endocochlear potential was recorded from the basal turn of scala media, before and after phenylephrine injection. The composition of the perilymph and the kinetic constants for (14)C-urea and (3)H-mannitol were similar in WKY and SHR, and not modified after acute hypertension. In endolymph, the endocochlear potential in SHR (+80+/-2.7 mV, n=24) was lower (P<0.001) than in WKY (+98+/-1.5 mV, n=29). The endocochlear potential was decreased by 40 mV during acute hypertensive peak in seven out of 19 WKY but not in SHR rats (n=13). In conclusion, chronic or acute hypertension did not severely alter the permeability to small molecules of the blood-perilymph barrier. The relationship between the low endocochlear potential and hypertension in SHR remains to be evaluated. After acute hypertensive peak, the presence of vascular protective mechanisms in the cochlea could account for the stable endocochlear potential recorded in SHR and 60% of normotensive rats.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Chronic Disease</subject><subject>Cochlea - physiopathology</subject><subject>Ear, Inner - physiopathology</subject><subject>Endolymph - physiology</subject><subject>Experimental diseases</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Mannitol - cerebrospinal fluid</subject><subject>Mannitol - pharmacokinetics</subject><subject>Medical sciences</subject><subject>Membrane Potentials</subject><subject>Perilymph - physiology</subject><subject>Permeability</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred WKY</subject><subject>Urea - cerebrospinal fluid</subject><subject>Urea - pharmacokinetics</subject><issn>0378-5955</issn><issn>1878-5891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNpFkF1LwzAUQIMobk5_ghIQRB-qN03atI8y5gdMfHAPewtpmtBIl84kfdi_t9uKQuBCOOdeOAhdE3gkQPKnL6C8SLIyy-4BHgDStEzWJ2hKiv13UZJTNP1DJugihG8AklGWnqMJISRlLC-m6GNhjFYx4M5gqfqosXQ1Vo3vnFW42W21j9oF2zk8vNho3Mpq562LjXUaV9J7q33A1mEv4yU6M7IN-mqcM7R6Wazmb8ny8_V9_rxMFKU0JhVP65TnBqiknPNc1SWrJCe1rFgNxOSy4jQtGMkZM1DlLGMSFM9SGCwCdIbujmu3vvvpdYhiY4PSbSud7vogOGR80MsBzI6g8l0IXhux9XYj_U4QEPuM4pBR7BsJAHHIKNaDdzMe6KuNrv-tsdsA3I6ADEq2xkunbPjjypJTmtNfCYx5qw</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>MOSNIER, Isabelle</creator><creator>TEIXEIRA, Marie</creator><creator>LOISEAU, Alain</creator><creator>FERNANDES, Isabelle</creator><creator>STERKERS, Olivier</creator><creator>AMIEL, Claude</creator><creator>FERRARY, Evelyne</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>2001</creationdate><title>Effects of acute and chronic hypertension on the labyrinthine barriers in rat</title><author>MOSNIER, Isabelle ; TEIXEIRA, Marie ; LOISEAU, Alain ; FERNANDES, Isabelle ; STERKERS, Olivier ; AMIEL, Claude ; FERRARY, Evelyne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-b72d276f03a37776cd94ba71dab4d01f6ab732841644f0b6454a0c7520276103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Acute Disease</topic><topic>Animals</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Chronic Disease</topic><topic>Cochlea - physiopathology</topic><topic>Ear, Inner - physiopathology</topic><topic>Endolymph - physiology</topic><topic>Experimental diseases</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Mannitol - cerebrospinal fluid</topic><topic>Mannitol - pharmacokinetics</topic><topic>Medical sciences</topic><topic>Membrane Potentials</topic><topic>Perilymph - physiology</topic><topic>Permeability</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred WKY</topic><topic>Urea - cerebrospinal fluid</topic><topic>Urea - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MOSNIER, Isabelle</creatorcontrib><creatorcontrib>TEIXEIRA, Marie</creatorcontrib><creatorcontrib>LOISEAU, Alain</creatorcontrib><creatorcontrib>FERNANDES, Isabelle</creatorcontrib><creatorcontrib>STERKERS, Olivier</creatorcontrib><creatorcontrib>AMIEL, Claude</creatorcontrib><creatorcontrib>FERRARY, Evelyne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Hearing research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MOSNIER, Isabelle</au><au>TEIXEIRA, Marie</au><au>LOISEAU, Alain</au><au>FERNANDES, Isabelle</au><au>STERKERS, Olivier</au><au>AMIEL, Claude</au><au>FERRARY, Evelyne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of acute and chronic hypertension on the labyrinthine barriers in rat</atitle><jtitle>Hearing research</jtitle><addtitle>Hear Res</addtitle><date>2001</date><risdate>2001</risdate><volume>151</volume><issue>1-2</issue><spage>227</spage><epage>236</epage><pages>227-236</pages><issn>0378-5955</issn><eissn>1878-5891</eissn><coden>HERED3</coden><abstract>Hearing loss, vertigo, and tinnitus have been related to arterial hypertension. The aim of the present work was to study the permeability of the blood-perilymph and of the labyrinthine barrier, between endolymph and perilymph, to small molecules during chronic and acute hypertension. Experiments were performed in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Acute hypertension was induced by phenylephrine. Perilymph was sampled from the first turn of the scala vestibuli and the Na, K, urea, and radioactive concentrations ((14)C-urea and (3)H-mannitol) were measured. In another experimental set, the endocochlear potential was recorded from the basal turn of scala media, before and after phenylephrine injection. The composition of the perilymph and the kinetic constants for (14)C-urea and (3)H-mannitol were similar in WKY and SHR, and not modified after acute hypertension. In endolymph, the endocochlear potential in SHR (+80+/-2.7 mV, n=24) was lower (P<0.001) than in WKY (+98+/-1.5 mV, n=29). The endocochlear potential was decreased by 40 mV during acute hypertensive peak in seven out of 19 WKY but not in SHR rats (n=13). In conclusion, chronic or acute hypertension did not severely alter the permeability to small molecules of the blood-perilymph barrier. The relationship between the low endocochlear potential and hypertension in SHR remains to be evaluated. After acute hypertensive peak, the presence of vascular protective mechanisms in the cochlea could account for the stable endocochlear potential recorded in SHR and 60% of normotensive rats.</abstract><cop>Amsterdam</cop><pub>Elsevier</pub><pmid>11124468</pmid><doi>10.1016/S0378-5955(00)00229-X</doi><tpages>10</tpages></addata></record> |
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| ispartof | Hearing research, 2001, Vol.151 (1-2), p.227-236 |
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| subjects | Acute Disease Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Chronic Disease Cochlea - physiopathology Ear, Inner - physiopathology Endolymph - physiology Experimental diseases Hypertension - physiopathology Male Mannitol - cerebrospinal fluid Mannitol - pharmacokinetics Medical sciences Membrane Potentials Perilymph - physiology Permeability Rats Rats, Inbred SHR Rats, Inbred WKY Urea - cerebrospinal fluid Urea - pharmacokinetics |
| title | Effects of acute and chronic hypertension on the labyrinthine barriers in rat |
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