Retinal fluorescein and indocyanine green angiography and optical coherence tomography in successive stages of Vogt-Koyanagi-Harada disease

• Published in: International ophthalmology 2007-06, Vol.27 (2-3), p.163-172
• Main Authors: Fardeau, Christine, Tran, Thi Ha Chau, Gharbi, Badra, Cassoux, Nathalie, Bodaghi, Bahram, LeHoang, Phuc
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Angiography; Child; Coloring Agents; Diagnosis; Epithelium; Female; Fluorescein; Fluorescein Angiography - methods; Fluorescence; Health services; Humans; Immunosuppressive agents; Indocyanine Green; Ischemia; Male; Medical imaging; Middle Aged; Optical Coherence Tomography; Perfusion; Retina; Retina - pathology; Retinal detachment; Retinal pigment epithelium; Retrospective Studies; Stroma; Tapering; Tomography; Tomography, Optical Coherence - methods; Uveomeningoencephalitic Syndrome - classification; Uveomeningoencephalitic Syndrome - diagnosis
• ISSN: 0165-5701; 1573-2630
• DOI: 10.1007/s10792-006-9024-7

To report features of retinal fluorescein (FA) and indocyanine green (ICGA) angiography and optical coherence tomography (OCT) at successive stages of Vogt-Koyanagi-Harada (VKH) disease. FA and ICGA were systematically performed in cases of VKH disease, at admission, 1 month later, and at the end of the follow-up. In addition, the most recent patients underwent OCT. In the follow-up, the clinical evolution and extent of treatment were related to the angiographic and tomographic features. FA and ICGA showed a diffuse delayed choroidal perfusion, including a delayed arterial, choriocapillar, and venous filling. This delayed choroidal perfusion involved the posterior pole and the hole periphery. The classically described serous retinal detachments were slowly filled from numerous pin points that could correspond to leakage through areas of damaged retinal pigment epithelium due to the choroidal ischemia. An uneven background choroidal fluorescence visible at the mid phase of ICGA was the result of multiple hypofluorescent round lesions in the choroidal stroma. Choroidal folds appeared hypofluorescent in FA and hyperfluorescent in ICGA. Some of these angiographic findings were present at the very early neurologic stage of the disease. Moreover, under treatment, a persisting altered choroidal perfusion could increase the incidence of retinal detachment relapses. Various pathological conditions are characterized by choroidal involvement and serous retinal detachment. Angiographical findings may be helpful in the diagnosis. FA coupled with ICGA can be an useful tool in the early diagnosis of VKH disease as well as during the tapering of immunosuppressive drugs.