INTERLEUKIN (IL-)15 HAS LESS ACTIVITY THAN IL-2 TO PROMOTE TYPE 2 CYTOKINE PREDOMINANCE IN TUMOUR-ASSOCIATED MONONUCLEAR CELLS FROM LUNG CANCER PATIENTS

• Published in: Cytokine (Philadelphia, Pa.) Pa.), 2001-01, Vol.13 (2), p.119-123
• Main Authors: Takeuchi, Eiji, Yanagawa, Hiroaki, Suzuki, Yoshihiro, Shinkawa, Kunihiro, Bando, Hiroyasu, Sone, Saburo
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Burkitt Lymphoma - metabolism; Carcinoma, Non-Small-Cell Lung - blood; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Small Cell - blood; Carcinoma, Small Cell - metabolism; Disease Progression; Female; Humans; Immunoenzyme Techniques; Interferon-gamma - biosynthesis; Interleukin-15 - metabolism; Interleukin-15 - pharmacology; Interleukin-2 - metabolism; Interleukin-2 - pharmacology; Interleukin-4 - biosynthesis; Interleukin-5 - biosynthesis; Leukocytes, Mononuclear - metabolism; Lung Neoplasms - blood; Lung Neoplasms - metabolism; Major Histocompatibility Complex; Male; Middle Aged; Pleural Effusion - metabolism; Tumor Cells, Cultured
• ISSN: 1043-4666; 1096-0023
• DOI: 10.1006/cyto.2000.0808

Deviation of type 1/type 2 cytokine balance to type 2 predominance may contribute to tumour progression. We investigated effect of interleukin (IL-)15 on modulation of type 1/type 2 balance in addition to non-major histo-compatibility complex (MHC)-restricted killer induction in the tumour-growing site. IL-15 induced significant killer activity in mononuclear cells (MNC) in malignant pleural effusion as well as those in peripheral blood. Pleural MNC produced more IFN-γ (type 1 cytokine) by incubation with IL-15 or IL-2 than blood MNC. Moreover, IL-4 and IL-5 (type 2 cytokines) production by pleural MNC were observed only by incubation with IL-2, but not with IL-15. These observations suggest that IL-15 has a potent activity to restore type 1/type 2 balance in addition to killer induction in tumour-growing site.