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Urinary levels of substance P and its metabolites are not increased in interstitial cystitis

Objectives To determine whether interstitial cystitis is associated with the increased release of substance P from the bladder wall into urine, by measuring urinary excretion rates of substance P and its metabolites in women with interstitial cystitis and in a control group of women with stress inco...

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Bibliographic Details
Published in:BJU international 2001-01, Vol.87 (1), p.35-38
Main Authors: Campbell, D.J., Tenis, N., Rosamilia, A., Clements, J.A., Dwyer, P.L.
Format: Article
Language:English
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Summary:Objectives To determine whether interstitial cystitis is associated with the increased release of substance P from the bladder wall into urine, by measuring urinary excretion rates of substance P and its metabolites in women with interstitial cystitis and in a control group of women with stress incontinence and normal bladder function. Patients and methods Catheter urine was collected from 13 patients and 10 controls during a water diuresis (≈ 10 mL/min) before and after instilling the bladder with 100 mL of water. The contribution of the bladder wall to urinary substance P peptides was assessed by measuring the change in substance P peptide levels after 2 min of bladder stasis before and after instillation. Results Absolute substance P excretion rates were similar in patients with interstitial cystitis and controls; 2 min of bladder stasis reduced the substance P excretion rate (P = 0.03) and increased the excretion rate of substance P metabolites (P = 0.01). Conclusions The release of substance P from the bladder wall was not increased in patients with interstitial cystitis.
ISSN:1464-4096
1464-410X
DOI:10.1046/j.1464-410x.2001.00990.x