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Expression of Cyclooxygenase-2 in Canine Renal Cell Carcinoma
Cyclooxygenase-2 (COX-2) has been shown to be the primary enzyme responsible for prostaglandin production during inflammation but is absent in most tissues under normal physiological states. High levels of COX-2 expression have been observed in the macula densa and thick ascending limbs of fetal kid...
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| Published in: | Veterinary pathology 2001-01, Vol.38 (1), p.116-119 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c384t-c839a710e6153c13eec62553a752c381d76fd2299c4c77613de8b9e84deae6003 |
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| cites | cdi_FETCH-LOGICAL-c384t-c839a710e6153c13eec62553a752c381d76fd2299c4c77613de8b9e84deae6003 |
| container_end_page | 119 |
| container_issue | 1 |
| container_start_page | 116 |
| container_title | Veterinary pathology |
| container_volume | 38 |
| creator | M. Khan, K. N. Stanfield, K. M. Trajkovic, D. Knapp, D. W. |
| description | Cyclooxygenase-2 (COX-2) has been shown to be the primary enzyme responsible for prostaglandin production during inflammation but is absent in most tissues under normal physiological states. High levels of COX-2 expression have been observed in the macula densa and thick ascending limbs of fetal kidneys; this expression declines to minimal levels during renal maturation. We hypothesized that the neoplastic cells of renal cell carcinoma (RCC) may revert to high expression of COX-2, and we evaluated its expression in three spontaneous cases of canine RCC by using immunohistochemical methods. The neoplastic cells of two of the three cases exhibited moderate to marked COX-2 immunoreactivity. These results suggest that some canine renal cell carcinomas express high levels of COX-2, which may play a role in the modulation of neoplastic cell growth. |
| doi_str_mv | 10.1354/vp.38-1-116 |
| format | article |
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Khan, K. N. ; Stanfield, K. M. ; Trajkovic, D. ; Knapp, D. W.</creator><creatorcontrib>M. Khan, K. N. ; Stanfield, K. M. ; Trajkovic, D. ; Knapp, D. W.</creatorcontrib><description>Cyclooxygenase-2 (COX-2) has been shown to be the primary enzyme responsible for prostaglandin production during inflammation but is absent in most tissues under normal physiological states. High levels of COX-2 expression have been observed in the macula densa and thick ascending limbs of fetal kidneys; this expression declines to minimal levels during renal maturation. We hypothesized that the neoplastic cells of renal cell carcinoma (RCC) may revert to high expression of COX-2, and we evaluated its expression in three spontaneous cases of canine RCC by using immunohistochemical methods. The neoplastic cells of two of the three cases exhibited moderate to marked COX-2 immunoreactivity. These results suggest that some canine renal cell carcinomas express high levels of COX-2, which may play a role in the modulation of neoplastic cell growth.</description><identifier>ISSN: 0300-9858</identifier><identifier>EISSN: 1544-2217</identifier><identifier>DOI: 10.1354/vp.38-1-116</identifier><identifier>PMID: 11199159</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animals ; Carcinoma, Renal Cell - enzymology ; Carcinoma, Renal Cell - genetics ; Carcinoma, Renal Cell - pathology ; Carcinoma, Renal Cell - veterinary ; Cyclooxygenase 2 ; Dog Diseases - enzymology ; Dog Diseases - genetics ; Dog Diseases - pathology ; Dogs ; Female ; Gene Expression Regulation, Neoplastic ; Immunohistochemistry - veterinary ; Isoenzymes - biosynthesis ; Isoenzymes - genetics ; Kidney - pathology ; Kidney Neoplasms - enzymology ; Kidney Neoplasms - genetics ; Kidney Neoplasms - pathology ; Kidney Neoplasms - veterinary ; Male ; Prostaglandin-Endoperoxide Synthases - biosynthesis ; Prostaglandin-Endoperoxide Synthases - genetics</subject><ispartof>Veterinary pathology, 2001-01, Vol.38 (1), p.116-119</ispartof><rights>2001 American College of Veterinary Pathologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-c839a710e6153c13eec62553a752c381d76fd2299c4c77613de8b9e84deae6003</citedby><cites>FETCH-LOGICAL-c384t-c839a710e6153c13eec62553a752c381d76fd2299c4c77613de8b9e84deae6003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11199159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>M. Khan, K. N.</creatorcontrib><creatorcontrib>Stanfield, K. M.</creatorcontrib><creatorcontrib>Trajkovic, D.</creatorcontrib><creatorcontrib>Knapp, D. W.</creatorcontrib><title>Expression of Cyclooxygenase-2 in Canine Renal Cell Carcinoma</title><title>Veterinary pathology</title><addtitle>Vet Pathol</addtitle><description>Cyclooxygenase-2 (COX-2) has been shown to be the primary enzyme responsible for prostaglandin production during inflammation but is absent in most tissues under normal physiological states. High levels of COX-2 expression have been observed in the macula densa and thick ascending limbs of fetal kidneys; this expression declines to minimal levels during renal maturation. We hypothesized that the neoplastic cells of renal cell carcinoma (RCC) may revert to high expression of COX-2, and we evaluated its expression in three spontaneous cases of canine RCC by using immunohistochemical methods. The neoplastic cells of two of the three cases exhibited moderate to marked COX-2 immunoreactivity. These results suggest that some canine renal cell carcinomas express high levels of COX-2, which may play a role in the modulation of neoplastic cell growth.</description><subject>Animals</subject><subject>Carcinoma, Renal Cell - enzymology</subject><subject>Carcinoma, Renal Cell - genetics</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Carcinoma, Renal Cell - veterinary</subject><subject>Cyclooxygenase 2</subject><subject>Dog Diseases - enzymology</subject><subject>Dog Diseases - genetics</subject><subject>Dog Diseases - pathology</subject><subject>Dogs</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Immunohistochemistry - veterinary</subject><subject>Isoenzymes - biosynthesis</subject><subject>Isoenzymes - genetics</subject><subject>Kidney - pathology</subject><subject>Kidney Neoplasms - enzymology</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - veterinary</subject><subject>Male</subject><subject>Prostaglandin-Endoperoxide Synthases - biosynthesis</subject><subject>Prostaglandin-Endoperoxide Synthases - genetics</subject><issn>0300-9858</issn><issn>1544-2217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNptkM9LwzAYhoMobk5P3qUnESQzX9M06cGDlPkDBoLoOWTp19GxNjVZx_bfG9nAi5fvhY-Hl5eHkGtgU-Aie9j2U64oUID8hIxBZBlNU5CnZMw4Y7RQQo3IRQgrxtK0UPKcjACgKEAUY_I42_UeQ2hcl7g6Kfd27dxuv8TOBKRp0nRJabqmw-QjvtZJiet4jLdN51pzSc5qsw54dcwJ-XqefZavdP7-8lY-zanlKttQq3hhJDDMQXALHNHmqRDcSJFGAiqZ11XcVtjMSpkDr1AtClRZhQZzxviE3B56e---Bwwb3TbBximmQzcELZmQksssgvcH0HoXgsda975pjd9rYPrXlt72misNOtqK9M2xdli0WP2xRz0RuDsAwSxRr9zgo4Pwb9cPXYdwrg</recordid><startdate>200101</startdate><enddate>200101</enddate><creator>M. 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Khan, K. N.</creatorcontrib><creatorcontrib>Stanfield, K. M.</creatorcontrib><creatorcontrib>Trajkovic, D.</creatorcontrib><creatorcontrib>Knapp, D. W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>M. Khan, K. N.</au><au>Stanfield, K. M.</au><au>Trajkovic, D.</au><au>Knapp, D. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Cyclooxygenase-2 in Canine Renal Cell Carcinoma</atitle><jtitle>Veterinary pathology</jtitle><addtitle>Vet Pathol</addtitle><date>2001-01</date><risdate>2001</risdate><volume>38</volume><issue>1</issue><spage>116</spage><epage>119</epage><pages>116-119</pages><issn>0300-9858</issn><eissn>1544-2217</eissn><abstract>Cyclooxygenase-2 (COX-2) has been shown to be the primary enzyme responsible for prostaglandin production during inflammation but is absent in most tissues under normal physiological states. High levels of COX-2 expression have been observed in the macula densa and thick ascending limbs of fetal kidneys; this expression declines to minimal levels during renal maturation. We hypothesized that the neoplastic cells of renal cell carcinoma (RCC) may revert to high expression of COX-2, and we evaluated its expression in three spontaneous cases of canine RCC by using immunohistochemical methods. The neoplastic cells of two of the three cases exhibited moderate to marked COX-2 immunoreactivity. These results suggest that some canine renal cell carcinomas express high levels of COX-2, which may play a role in the modulation of neoplastic cell growth.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>11199159</pmid><doi>10.1354/vp.38-1-116</doi><tpages>4</tpages></addata></record> |
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| issn | 0300-9858 1544-2217 |
| language | eng |
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| source | SAGE:Jisc Collections:SAGE Journals Read and Publish 2023-2024:2025 extension (reading list) |
| subjects | Animals Carcinoma, Renal Cell - enzymology Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology Carcinoma, Renal Cell - veterinary Cyclooxygenase 2 Dog Diseases - enzymology Dog Diseases - genetics Dog Diseases - pathology Dogs Female Gene Expression Regulation, Neoplastic Immunohistochemistry - veterinary Isoenzymes - biosynthesis Isoenzymes - genetics Kidney - pathology Kidney Neoplasms - enzymology Kidney Neoplasms - genetics Kidney Neoplasms - pathology Kidney Neoplasms - veterinary Male Prostaglandin-Endoperoxide Synthases - biosynthesis Prostaglandin-Endoperoxide Synthases - genetics |
| title | Expression of Cyclooxygenase-2 in Canine Renal Cell Carcinoma |
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