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Merkel cell carcinoma metastasizing to the kidney mimicking primary neuroendocrine renal cancer
A 56‐year‐old male with a history of cutaneous neuroendocrine (Merkel cell) carcinoma presented with a solid mass of the left kidney, measuring 10 cm in largest diameter. On histology, the tumour was composed of loosely packed uniform cells with round‐to‐oval nuclei and scant cytoplasm. Immunohistoc...
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| Published in: | APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2007-06, Vol.115 (6), p.774-777 |
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| container_end_page | 777 |
| container_issue | 6 |
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| container_title | APMIS : acta pathologica, microbiologica et immunologica Scandinavica |
| container_volume | 115 |
| creator | POLLHEIMER, VERENA S. BODO, KOPPANY POLLHEIMER, MARION J. ZIGEUNER, RICHARD LANGNER, CORD |
| description | A 56‐year‐old male with a history of cutaneous neuroendocrine (Merkel cell) carcinoma presented with a solid mass of the left kidney, measuring 10 cm in largest diameter. On histology, the tumour was composed of loosely packed uniform cells with round‐to‐oval nuclei and scant cytoplasm. Immunohistochemically, the tumour cells diffusely expressed pancytokeratin and neuroendocrine markers, such as chromogranin A, synaptophysin and CD56 (NCAM). Distinct paranuclear dot‐like expression of cytokeratin 20 showed the lesion to be metastatic Merkel cell carcinoma. This is the first reported case of Merkel cell carcinoma metastatic to the kidney mimicking primary neuroendocrine renal cancer. We discuss the differential diagnosis of the tumour and perform a systematic literature review, including potential indications for renal tumour biopsy in patients with a history of nonrenal malignancy. |
| doi_str_mv | 10.1111/j.1600-0463.2007.apm_617.x |
| format | article |
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On histology, the tumour was composed of loosely packed uniform cells with round‐to‐oval nuclei and scant cytoplasm. Immunohistochemically, the tumour cells diffusely expressed pancytokeratin and neuroendocrine markers, such as chromogranin A, synaptophysin and CD56 (NCAM). Distinct paranuclear dot‐like expression of cytokeratin 20 showed the lesion to be metastatic Merkel cell carcinoma. This is the first reported case of Merkel cell carcinoma metastatic to the kidney mimicking primary neuroendocrine renal cancer. We discuss the differential diagnosis of the tumour and perform a systematic literature review, including potential indications for renal tumour biopsy in patients with a history of nonrenal malignancy.</description><identifier>ISSN: 0903-4641</identifier><identifier>EISSN: 1600-0463</identifier><identifier>DOI: 10.1111/j.1600-0463.2007.apm_617.x</identifier><identifier>PMID: 17550389</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biological and medical sciences ; carcinoma metastatic to the kidney ; Carcinoma, Merkel Cell - classification ; Carcinoma, Merkel Cell - metabolism ; Carcinoma, Merkel Cell - pathology ; Carcinoma, Neuroendocrine - pathology ; Carcinoma, Neuroendocrine - physiopathology ; differential diagnosis ; Fundamental and applied biological sciences. Psychology ; Humans ; Infectious diseases ; Kidney Neoplasms - secondary ; Male ; Medical sciences ; Merkel cell carcinoma ; Microbiology ; Middle Aged ; Neoplasm Metastasis ; neuroendocrine carcinoma of the kidney ; Tumors</subject><ispartof>APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2007-06, Vol.115 (6), p.774-777</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2347-9175f4b72a36a33823834b485bf126287dc59a97a9b4606913ecc729bfd4c523</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18818140$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17550389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>POLLHEIMER, VERENA S.</creatorcontrib><creatorcontrib>BODO, KOPPANY</creatorcontrib><creatorcontrib>POLLHEIMER, MARION J.</creatorcontrib><creatorcontrib>ZIGEUNER, RICHARD</creatorcontrib><creatorcontrib>LANGNER, CORD</creatorcontrib><title>Merkel cell carcinoma metastasizing to the kidney mimicking primary neuroendocrine renal cancer</title><title>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</title><addtitle>APMIS</addtitle><description>A 56‐year‐old male with a history of cutaneous neuroendocrine (Merkel cell) carcinoma presented with a solid mass of the left kidney, measuring 10 cm in largest diameter. On histology, the tumour was composed of loosely packed uniform cells with round‐to‐oval nuclei and scant cytoplasm. Immunohistochemically, the tumour cells diffusely expressed pancytokeratin and neuroendocrine markers, such as chromogranin A, synaptophysin and CD56 (NCAM). Distinct paranuclear dot‐like expression of cytokeratin 20 showed the lesion to be metastatic Merkel cell carcinoma. This is the first reported case of Merkel cell carcinoma metastatic to the kidney mimicking primary neuroendocrine renal cancer. We discuss the differential diagnosis of the tumour and perform a systematic literature review, including potential indications for renal tumour biopsy in patients with a history of nonrenal malignancy.</description><subject>Biological and medical sciences</subject><subject>carcinoma metastatic to the kidney</subject><subject>Carcinoma, Merkel Cell - classification</subject><subject>Carcinoma, Merkel Cell - metabolism</subject><subject>Carcinoma, Merkel Cell - pathology</subject><subject>Carcinoma, Neuroendocrine - pathology</subject><subject>Carcinoma, Neuroendocrine - physiopathology</subject><subject>differential diagnosis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Kidney Neoplasms - secondary</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Merkel cell carcinoma</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>neuroendocrine carcinoma of the kidney</subject><subject>Tumors</subject><issn>0903-4641</issn><issn>1600-0463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNpFkV1rFDEUhoModlv9CzIIejdjviYfN0Ip2iptFSz0MmQyZzS7M5ltMou7_fVm2LENh-SQ8_CSNy9C7wmuSF6f1hURGJeYC1ZRjGVlt4MRRFb7F2j1NHqJVlhjVnLByQk6TWmNMaFKyNfohMi6xkzpFTI3EDfQFw76vNnofBgHWwww2ZTLP_rwu5jGYvoDxca3AQ7F4AfvNvP9NvrBxkMRYBdHCO3oog9QRAh2FgsO4hv0qrN9grfLeYbuvn65u7gqr39cfrs4vy4dZVyWOr-o442klgnLmKJMMd5wVTcdoYIq2bpaWy2tbrjAQhMGzkmqm67lrqbsDH08ym7j-LCDNJnBp9mTDTDukpG4llJwncF3C7hrBmjNYsH8_5EMfFgAm5ztu5ht-PTMKUUU4Thzn4_cX9_D4XmOzZyRWZs5CDMHYeaMzJKR2Zvznze5yQLlUcCnCfZPAjZujJBM1ub-9tKIX5zdivvv5or9AxYWlTc</recordid><startdate>200706</startdate><enddate>200706</enddate><creator>POLLHEIMER, VERENA S.</creator><creator>BODO, KOPPANY</creator><creator>POLLHEIMER, MARION J.</creator><creator>ZIGEUNER, RICHARD</creator><creator>LANGNER, CORD</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200706</creationdate><title>Merkel cell carcinoma metastasizing to the kidney mimicking primary neuroendocrine renal cancer</title><author>POLLHEIMER, VERENA S. ; BODO, KOPPANY ; POLLHEIMER, MARION J. ; ZIGEUNER, RICHARD ; LANGNER, CORD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2347-9175f4b72a36a33823834b485bf126287dc59a97a9b4606913ecc729bfd4c523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biological and medical sciences</topic><topic>carcinoma metastatic to the kidney</topic><topic>Carcinoma, Merkel Cell - classification</topic><topic>Carcinoma, Merkel Cell - metabolism</topic><topic>Carcinoma, Merkel Cell - pathology</topic><topic>Carcinoma, Neuroendocrine - pathology</topic><topic>Carcinoma, Neuroendocrine - physiopathology</topic><topic>differential diagnosis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Kidney Neoplasms - secondary</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Merkel cell carcinoma</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>neuroendocrine carcinoma of the kidney</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>POLLHEIMER, VERENA S.</creatorcontrib><creatorcontrib>BODO, KOPPANY</creatorcontrib><creatorcontrib>POLLHEIMER, MARION J.</creatorcontrib><creatorcontrib>ZIGEUNER, RICHARD</creatorcontrib><creatorcontrib>LANGNER, CORD</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>POLLHEIMER, VERENA S.</au><au>BODO, KOPPANY</au><au>POLLHEIMER, MARION J.</au><au>ZIGEUNER, RICHARD</au><au>LANGNER, CORD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Merkel cell carcinoma metastasizing to the kidney mimicking primary neuroendocrine renal cancer</atitle><jtitle>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</jtitle><addtitle>APMIS</addtitle><date>2007-06</date><risdate>2007</risdate><volume>115</volume><issue>6</issue><spage>774</spage><epage>777</epage><pages>774-777</pages><issn>0903-4641</issn><eissn>1600-0463</eissn><abstract>A 56‐year‐old male with a history of cutaneous neuroendocrine (Merkel cell) carcinoma presented with a solid mass of the left kidney, measuring 10 cm in largest diameter. 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| issn | 0903-4641 1600-0463 |
| language | eng |
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| source | Wiley |
| subjects | Biological and medical sciences carcinoma metastatic to the kidney Carcinoma, Merkel Cell - classification Carcinoma, Merkel Cell - metabolism Carcinoma, Merkel Cell - pathology Carcinoma, Neuroendocrine - pathology Carcinoma, Neuroendocrine - physiopathology differential diagnosis Fundamental and applied biological sciences. Psychology Humans Infectious diseases Kidney Neoplasms - secondary Male Medical sciences Merkel cell carcinoma Microbiology Middle Aged Neoplasm Metastasis neuroendocrine carcinoma of the kidney Tumors |
| title | Merkel cell carcinoma metastasizing to the kidney mimicking primary neuroendocrine renal cancer |
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