Quantitative determination of age-related geometric changes in the normal abdominal aorta

Purpose: We conducted a novel quantitative three-dimensional analysis of computed tomography (CT) angiograms to establish the relationship between aortic geometry and age, sex, and body surface area in healthy subjects. Methods: Abdominal helical CT angiograms from 77 healthy potential renal donors...

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Bibliographic Details
Published in:Journal of vascular surgery 2001-01, Vol.33 (1), p.97-105
Main Authors: Fleischmann, Dominik, Hastie, Trevor J., Dannegger, Felix C., Paik, David S., Tillich, Manfred, Zarins, Christopher K., Rubin, Geoffrey D.
Format: Article
Language:English
Subjects:
Adult
Aged
Aging - physiology
Aorta, Abdominal - anatomy & histology
Aortography
Biological and medical sciences
Cardiovascular system
Female
Humans
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Reference Values
Tomography, X-Ray Computed
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Summary:Purpose: We conducted a novel quantitative three-dimensional analysis of computed tomography (CT) angiograms to establish the relationship between aortic geometry and age, sex, and body surface area in healthy subjects. Methods: Abdominal helical CT angiograms from 77 healthy potential renal donors (33 men/44 women; mean age, 44 years; age range, 19-67 years) were selected. In each dataset, orthonormal cross-sectional area and diameter measurements were obtained at 1-mm intervals along the automatically calculated central axis of the abdominal aorta. The aorta was subdivided into six consecutive anatomic segments (supraceliac, supramesenteric, suprarenal, inter-renal, proximal infrarenal, and distal infrarenal). The interrelated effects of anatomic segment, age, sex, and body surface area on cross-sectional dimensions were analyzed with linear mixed-effects and varying-coefficient statistical models. Results: We found that significant effects of sex and of body surface area on aortic diameters were similar at all anatomic levels. The effect of age, however, was interrelated with anatomic position, and gradually decreasing slopes of significant diameter-versus-age relationships along the aorta, which ranged from 0.14 mm/y (P
ISSN:0741-5214
1097-6809
DOI:10.1067/mva.2001.109764