Phylogenetic Distribution of Extraintestinal Virulence-Associated Traits in Escherichia coli

The 72 member strains of the Escherichia coli Reference collection were assessed as to genotype for 31 putative extraintestinal virulence factor (VF) genes and DNA sequence for papA, the P fimbrial structural subunit gene. Although most VFs were concentrated in phylogenetic group B2 or jointly in gr...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 2001-01, Vol.183 (1), p.78-88
Main Authors: Johnson, James R., Delavari, Parissa, Kuskowski, Michael, Stell, Adam L.
Format: Article
Language:English
Subjects:
Alleles
Animals
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Bacterial Proteins - genetics
Bacteriology
Biological and medical sciences
Escherichia coli
Escherichia coli - chemistry
Escherichia coli - genetics
Escherichia coli - pathogenicity
Escherichia coli Infections - microbiology
Escherichia coli Proteins
Feces - microbiology
Fimbriae Proteins
Fundamental and applied biological sciences. Psychology
Genes, Bacterial
Genotype
Genotypes
Human bacterial diseases
Humans
Infectious diseases
Major Articles
Medical sciences
Microbiology
Molecular Sequence Data
papA gene
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Phylogenetics
Phylogeny
Polymerase chain reaction
Primates
Reference Standards
Urinary tract infections
Virulence
Virulence - genetics
Virulence factors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The 72 member strains of the Escherichia coli Reference collection were assessed as to genotype for 31 putative extraintestinal virulence factor (VF) genes and DNA sequence for papA, the P fimbrial structural subunit gene. Although most VFs were concentrated in phylogenetic group B2 or jointly in groups B2 and D, others were concentrated primarily in group D, were broadly distributed (without group-specific associations), and/or occurred only outside of group B2. Statistical correlations among VFs suggested linkage on pathogenicity-associated islands or plasmids. Isolates from humans and nonhuman primates had more VFs than did isolates from other animals. Sequence diversity was minimal within each F type-specific papA allele group but was substantial among different papA allele groups. The distribution patterns of papA variants and other VFs suggested multiple horizontal transfer events. These findings provide new insights into the phylogenetic origins of extraintestinal VFs in E. coli.
ISSN:0022-1899
1537-6613
DOI:10.1086/317656