Prevention of severe ovarian hyperstimulation syndrome in IVF with or without ICSI and embryo transfer: a modified `coasting' strategy based on ultrasound for identification of high-risk patients

Ovarian hyperstimulation syndrome (OHSS) can be a severe and potentially life-threatening complication of ovarian stimulation for IVF. Coasting or withholding gonadotrophin stimulation relies on frequent estimation of serum oestradiol to identify patients at risk. A modified coasting protocol was de...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2001-01, Vol.16 (1), p.24-30
Main Authors: Al-Shawaf, T., Zosmer, A., Hussain, S., Tozer, A., Panay, N., Wilson, C., Lower, A.M., Grudzinskas, J.G.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Chorionic Gonadotropin - administration & dosage
coasting
Embryo Transfer
Estradiol - blood
Female
Female genital diseases
Fertilization in Vitro - adverse effects
Gynecology. Andrology. Obstetrics
Humans
Male
Medical sciences
Non tumoral diseases
oestradiol
Ovarian Follicle - diagnostic imaging
ovarian hyperstimulation syndrome
Ovarian Hyperstimulation Syndrome - diagnostic imaging
Ovarian Hyperstimulation Syndrome - prevention & control
ovarian stimulation
Ovulation Induction - adverse effects
Pregnancy
Risk Factors
Sperm Injections, Intracytoplasmic
Treatment Outcome
Ultrasonography
ultrasound
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Summary:Ovarian hyperstimulation syndrome (OHSS) can be a severe and potentially life-threatening complication of ovarian stimulation for IVF. Coasting or withholding gonadotrophin stimulation relies on frequent estimation of serum oestradiol to identify patients at risk. A modified coasting protocol was developed in which identification of patients at risk of severe OHSS was based on ultrasound monitoring. Serum oestradiol concentrations were measured only in patients with >20 follicles on ultrasound (high risk). If serum oestradiol concentrations were
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/16.1.24