De novo acute myeloid leukemia in the elderly; a consistent fraction of long-term survivors by standard-dose chemotherapy

• Published in: Leukemia research 2001, Vol.25 (1), p.33-38
• Main Authors: Yoshida, Shinichiro, Kuriyama, Kazutaka, Miyazaki, Yasushi, Taguchi, Jun, Fukushima, Takuya, Honda, Miyuki, Hayashibara, Toshihisa, Nagai, Kazuhiro, Atogami, Sunao, Toriya, Kazuhiro, Soda, Hisashi, Nonaka, Hiroaki, Momita, Saburo, Jinnai, Itsuro, Amenomori, Tatsuhiko, Kusano, Miyuki, Yoshida, Yoshiharu, Ikeda, Shuichi, Matsuo, Tatsuki, Tomonaga, Masao
• Format: Article
• Language: English
• Subjects: Acute Disease; Aged; Aged, 80 and over; Aging - pathology; Antineoplastic agents; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Chemotherapy; Clinical features; Cytarabine - administration & dosage; Daunorubicin - administration & dosage; De novo AML; Elderly patient; Female; Humans; Karyotyping; Leukemia, Myeloid - classification; Leukemia, Myeloid - drug therapy; Leukemia, Myeloid - genetics; Leukemia, Myeloid - mortality; Male; Medical sciences; Mercaptopurine - administration & dosage; Middle Aged; Pharmacology. Drug treatments; Prognosis; Prognostic factors; Standard chemotherapy; Treatment Outcome; Tretinoin - administration & dosage
• ISSN: 0145-2126; 1873-5835
• DOI: 10.1016/S0145-2126(00)00089-8

To clarify the characteristics of de novo acute myeloid leukemia (AML) among the elderly, we reviewed 112 patients over 60 years old (median age 72 years) who were treated at hospitals in Nagasaki Prefecture with a population of 1.5 million between 1987 and 1994. Reclassification of morphological diagnosis revealed that the proportion of M3 was lower but that of M6 and the incidence of cases with trilineage dysplasia (TLD), known as poor prognostic features, were higher in the elderly than in patients less than 60 years old. Similarly, chromosomal data showed a lower frequency of favorable karyotypes such as t(8;21) and t(15;17) in the elderly. The overall survival of all 112 patients was 10.3% at 5 years. Multivariate analysis indicated that good performance status (PS), low WBC at diagnosis, standard dose multi-drug chemotherapy and all-trans retinoic acid (ATRA) treatment for M3 patients, and morphological findings without TLD were significantly correlated with longer survival. Most of the long-term survivors were found among those who received standard dose therapy in this series, although no consensus has been established how to treat elderly AML patients. We propose that a prospective controlled trial is necessary to confirm the role of standard dose chemotherapy for elderly patients with de novo AML.