Polymorphisms of the DNA Repair Gene XRCC1 and Lung Cancer Risk

We explored the association between polymorphisms of the DNA repair gene XRCC1 (codons 194, 280, and 399) and lung cancer risk in a case-control study nested within a cohort of tin miners. Cases were those diagnosed with lung cancer over 6 years of follow-up ( n = 108). Two controls, matched on age...

Full description

Saved in:
Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2001-02, Vol.10 (2), p.119-123
Main Authors: RATNASINGHE, Duminda, YAO, Shu-Xiang, TANGREA, Joseph A, QIAO, You-Lin, ANDERSEN, Mark R, BARRETT, Michael J, GIFFEN, Carol A, EROZAN, Yener, TOCKMAN, Melvyn S, TAYLOR, Philip R
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Aged
Base Sequence
Biological and medical sciences
Case-Control Studies
Cohort Studies
Confidence Intervals
DNA-Binding Proteins - genetics
Female
Humans
Incidence
Lung Neoplasms - epidemiology
Lung Neoplasms - genetics
Male
Medical sciences
Middle Aged
Molecular Sequence Data
Pneumology
Polymerase Chain Reaction
Polymorphism, Genetic
Prospective Studies
Risk Factors
Sex Distribution
Survival Rate
Tumors of the respiratory system and mediastinum
United States - epidemiology
X-ray Repair Cross Complementing Protein 1
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We explored the association between polymorphisms of the DNA repair gene XRCC1 (codons 194, 280, and 399) and lung cancer risk in a case-control study nested within a cohort of tin miners. Cases were those diagnosed with lung cancer over 6 years of follow-up ( n = 108). Two controls, matched on age and sex, were selected for each case by incidence density sampling. Of the three polymorphisms, only the XRCC1 Arg280His allele was associated with increased lung cancer risk (odds ratio, 1.8; 95% confidence interval, 1.0–3.4) after adjustment for radon and tobacco exposure. In addition, individuals with the variant Arg280His allele who were alcohol drinkers seemed to be at higher risk for lung cancer compared with those with the homozygous wild-type genotype. Conversely, individuals with the variant Arg194Trp allele who were alcohol drinkers seemed to be at lower risk for lung cancer compared with those with the homozygous wild-type genotype. Polymorphisms of XRCC1 appear to influence risk of lung cancer and may modify risk attributable to environmental exposures.
ISSN:1055-9965
1538-7755