Antileishmanial activity of indole alkaloids from Aspidosperma ramiflorum

The present study was designated to evaluate the antileishmanial activity of acid and basic fractions that were obtained after acid-basic extraction, from ethanolic 70% crude extract and pure compounds from the stem bark of Aspidosperma ramiflorum. The basic alkaloidal fraction presented a good acti...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2007-06, Vol.14 (6), p.377-380
Main Authors: Tanaka, J.C.A., da Silva, C.C., Ferreira, I.C.P., Machado, G.M.C., Leon, L.L., de Oliveira, A.J.B.
Format: Article
Language:English
Subjects:
Animals
Antileishmanial activity
Antiprotozoal Agents - chemistry
Antiprotozoal Agents - pharmacology
Aspidosperma - chemistry
Aspidosperma ramiflorum
Gram-positive bacteria
Indole
Indole Alkaloids - chemistry
Indole Alkaloids - pharmacology
Leishmania - drug effects
Leishmania amazonensis
Leishmaniasis
Molecular Conformation
Monoterpenoid indole alkaloids
Phytotherapy
Plant Bark - chemistry
Plant Stems - chemistry
Quebracho
Ramiflorines A and B
Risk factors
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Summary:The present study was designated to evaluate the antileishmanial activity of acid and basic fractions that were obtained after acid-basic extraction, from ethanolic 70% crude extract and pure compounds from the stem bark of Aspidosperma ramiflorum. The basic alkaloidal fraction presented a good activity against the extracellular form (promastigotes) of Leishmania (L.) amazonensis (LD 50 value
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2006.09.002