Sinonasal tract eosinophilic angiocentric fibrosis : A report of three cases

Eosinophilic angiocentric fibrosis (EAF) is a rare submucosal fibrosis without a well-developed differential diagnosis. Three cases of sinonasal tract EAF were identified in 2 women and 1 man, aged 49, 64, and 28 years, respectively. The patients experienced a nasal cavity mass, maxillary pain, or n...

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Bibliographic Details
Published in:American journal of clinical pathology 2001-02, Vol.115 (2), p.243-248
Main Authors: THOMPSON, Lester D. R, HEFFNER, Dennis K
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biomarkers - analysis
Eosinophilia - metabolism
Eosinophilia - pathology
Eosinophilia - surgery
Female
Fibrosis - metabolism
Fibrosis - pathology
Fibrosis - surgery
Humans
Immunohistochemistry
Male
Medical sciences
Middle Aged
Nasal Obstruction - etiology
Nasal Obstruction - pathology
Nose Diseases - metabolism
Nose Diseases - pathology
Nose Diseases - surgery
Otorhinolaryngology. Stomatology
Paranasal Sinuses - metabolism
Paranasal Sinuses - pathology
Paranasal Sinuses - surgery
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Eosinophilic angiocentric fibrosis (EAF) is a rare submucosal fibrosis without a well-developed differential diagnosis. Three cases of sinonasal tract EAF were identified in 2 women and 1 man, aged 49, 64, and 28 years, respectively. The patients experienced a nasal cavity mass, maxillary pain, or nasal obstructive symptoms of long duration. The process involved the nasal septum (n = 2), nasal cavity (n = 1), and/or the maxillary sinus (n = 1). There was no evidence for Wegener granulomatosis, Churg-Strauss syndrome, Kimura disease, granuloma faciale, or erythema elevatum diutinum. Histologically, the lesions demonstrated a characteristic perivascular "onion-skin" fibrosis and a full spectrum of inflammatory cells, although eosinophils predominated. Necrosis and foreign body-type giant cells were not identified. Surgical excision was used for all patients, who are all alive but with disease at last follow-up. Sinonasal tract EAF is a unique fibroproliferative disorder that does not seem to have systemic associations with known diseases. The characteristic histomorphologic features permit accurate diagnosis.
ISSN:0002-9173
1943-7722
DOI:10.1309/7D97-83KY-6NW2-5608