Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro

The action of antidepressants on cell proliferation {bromodeoxyuridine (BrdU) or [3H]thymidine incorporation} was studied in the adult rat hippocampus in vivo and in neural precursors (immature rat cerebellar granule cells) in vitro. In vivo, prolonged (21 days) but not acute (single) intraperitonea...

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Bibliographic Details
Published in:European journal of pharmacology 2001-01, Vol.411 (1-2), p.67-70
Main Authors: Manev, Hari, Uz, Tolga, Smalheiser, Neil R, Manev, Radmila
Format: Article
Language:English
Subjects:
Animals
Antidepressant
Antidepressive Agents - pharmacology
Biological and medical sciences
Brain - cytology
Brain - drug effects
Brain - metabolism
Cell Division - drug effects
Cells, Cultured
Cerebellar granule
Cerebellum - cytology
Cerebellum - drug effects
Cerebellum - metabolism
Clomipramine - pharmacology
Desipramine - pharmacology
Dose-Response Relationship, Drug
Fluoxetine
Fluoxetine - pharmacology
Hippocampus
Imipramine - pharmacology
Medical sciences
Nervous System - cytology
Nervous System - drug effects
Nervous System - metabolism
Neurogenesis
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Inbred BN
Rats, Sprague-Dawley
Thymidine - metabolism
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Summary:The action of antidepressants on cell proliferation {bromodeoxyuridine (BrdU) or [3H]thymidine incorporation} was studied in the adult rat hippocampus in vivo and in neural precursors (immature rat cerebellar granule cells) in vitro. In vivo, prolonged (21 days) but not acute (single) intraperitoneal treatment with fluoxetine (5 mg/kg) resulted in a 3.4-fold increase of bromodeoxyuridine-positive cells in the subgranular zone of the dentate gyrus. In cell cultures, at 1 and 10 days in vitro, 48-h fluoxetine exposure (1 μM, which is comparable to therapeutic plasma concentrations) reduced thymidine incorporation when initiated at 1 day in vitro, but increased cell proliferation when initiated at 10 days in vitro. Clomipramine and imipramine produced similar action in vitro; desipramine was ineffective.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(00)00904-3