Dermatofibroma‐like granular cell tumor

Background: There have been several reports in the literature of dermatofibromas with granular cells. Here we report a granular cell tumor with the architecture of a dermatofibroma. This is the first report of this histological variant of granular cell tumor. The lesion was a 2.5‐cm oval, hyperpigme...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2001-01, Vol.28 (1), p.49-52
Main Authors: Cheng, Stephanie D., Usmani, Arif S., DeYoung, Barry R., Ly, Micki, Pellegrini, Arthur E.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers, Tumor - analysis
Dermatology
Female
Granular Cell Tumor - chemistry
Granular Cell Tumor - pathology
Histiocytoma, Benign Fibrous - chemistry
Histiocytoma, Benign Fibrous - pathology
Humans
Medical sciences
Middle Aged
Neoplasm Proteins - analysis
Phosphopyruvate Hydratase - analysis
S100 Proteins - analysis
Skin Neoplasms - chemistry
Skin Neoplasms - pathology
Transglutaminases - analysis
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:Background: There have been several reports in the literature of dermatofibromas with granular cells. Here we report a granular cell tumor with the architecture of a dermatofibroma. This is the first report of this histological variant of granular cell tumor. The lesion was a 2.5‐cm oval, hyperpigmented plaque present for “years” on the back of a 60‐year‐old African‐American woman. Methods: The specimen was processed using formalin fixation and paraffin embedding. Tissue sections were stained with hematoxylin and eosin. Immunohistochemical studies were performed with antibodies directed against S‐100 protein, neuron‐specific enolase, and factor XIIIa. Results: Histopathologic examination revealed granular cells, some of which were spindle shaped, distributed singly and in small groups between collagen bundles resembling a dermatofibroma. Immunohistochemical studies showed the tumor cells to be positive for S‐100 and neuron‐specific enolase and negative for factor XIIIa. Conclusion: The immunohistochemical findings support the diagnosis of a granular cell tumor with a dermatofibroma‐like pattern.
ISSN:0303-6987
1600-0560
DOI:10.1034/j.1600-0560.2001.280106.x