Dermatofibroma‐like granular cell tumor

• Published in: Journal of cutaneous pathology 2001-01, Vol.28 (1), p.49-52
• Main Authors: Cheng, Stephanie D., Usmani, Arif S., DeYoung, Barry R., Ly, Micki, Pellegrini, Arthur E.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Biomarkers, Tumor - analysis; Dermatology; Female; Granular Cell Tumor - chemistry; Granular Cell Tumor - pathology; Histiocytoma, Benign Fibrous - chemistry; Histiocytoma, Benign Fibrous - pathology; Humans; Medical sciences; Middle Aged; Neoplasm Proteins - analysis; Phosphopyruvate Hydratase - analysis; S100 Proteins - analysis; Skin Neoplasms - chemistry; Skin Neoplasms - pathology; Transglutaminases - analysis; Tumors of the skin and soft tissue. Premalignant lesions
• ISSN: 0303-6987; 1600-0560
• DOI: 10.1034/j.1600-0560.2001.280106.x

Background: There have been several reports in the literature of dermatofibromas with granular cells. Here we report a granular cell tumor with the architecture of a dermatofibroma. This is the first report of this histological variant of granular cell tumor. The lesion was a 2.5‐cm oval, hyperpigmented plaque present for “years” on the back of a 60‐year‐old African‐American woman. Methods: The specimen was processed using formalin fixation and paraffin embedding. Tissue sections were stained with hematoxylin and eosin. Immunohistochemical studies were performed with antibodies directed against S‐100 protein, neuron‐specific enolase, and factor XIIIa. Results: Histopathologic examination revealed granular cells, some of which were spindle shaped, distributed singly and in small groups between collagen bundles resembling a dermatofibroma. Immunohistochemical studies showed the tumor cells to be positive for S‐100 and neuron‐specific enolase and negative for factor XIIIa. Conclusion: The immunohistochemical findings support the diagnosis of a granular cell tumor with a dermatofibroma‐like pattern.